IC-6

Base Information

• Chemical Name: IC-6
• CAS No.: 41537-67-1
• Molecular Formula: C24H32N2
• Molecular Weight: 348.52
• Mol file: 41537-67-1.mol

Synonyms:4-cyclohexyl-1-(1,2-diphenylethyl)piperazine;

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Chemical Property of IC-6

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 2.55E-08mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 450.838 °C at 760 mmHg
• Flash Point: 200.613 °C
• PSA: 6.48000
• Density: 1.073 g/cm³
• LogP: 4.79650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IC-6

There total 4 articles about IC-6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C17H24N2O + benzylmagnesium chloride (6921-34-2) → 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (52694-55-0,41537-67-1)

Guidance literature:

C₁₇H₂₄N₂O; With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane; In dichloromethane; at 20 ℃; for 0.333333h;

benzylmagnesium chloride; at -78 - 20 ℃; for 4h; chemoselective reaction;

DOI:10.1039/c7sc03613b

Reference yield:

(-)-1-cyclohexyl-4-<2-(3-nitrophenyl)-1-phenylethyl>piperazine dihydrochloride (109390-25-2) → (R)-(-)-1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (57377-70-5,41537-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, AcOH / 5percent Pd/C

2: 1.) 31.5percent aq. H₂SO₄, aq. NaNO₂, 2.) 30percent aq. H₃PO₂ / 1.) from 0 deg C to 5 deg C, 10 min

With sulfuric acid; hydrogen; hypophosphorous acid; acetic acid; sodium nitrite; palladium on activated charcoal;

DOI:10.1021/jm00393a017

Reference yield:

(-)-1-cyclohexyl-4-<2-(3-aminophenyl)-1-phenylethyl>piperazine (109364-53-6) → (R)-(-)-1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (57377-70-5,41537-67-1)

Guidance literature:

With sulfuric acid; hypophosphorous acid; sodium nitrite; Yield given. Multistep reaction; 1.) from 0 deg C to 5 deg C, 10 min;

DOI:10.1021/jm00393a017

upstream raw materials:

benzylmagnesium chloride

(-)-1-cyclohexyl-4-<2-(3-aminophenyl)-1-phenylethyl>piperazine

(-)-1-cyclohexyl-4-<2-(3-nitrophenyl)-1-phenylethyl>piperazine dihydrochloride

Refernces

• 1、 Natsuka,Nakamura,Nishikawa,Negoro,Uno,Nishimura. "Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity". . p. 1779 - 1787. Retrieved 2007/10/02.