(R)-Rivastigmine

Base Information

Chemical Name:(R)-Rivastigmine
CAS No.:415973-05-6
Molecular Formula:C14H22N2O2
Molecular Weight:250.33700
Hs Code.:2924299090
UNII:Z25UDQ15MV
DSSTox Substance ID:DTXSID90194422
Nikkaji Number:J2.138.266C
Wikidata:Q27294895
Mol file:415973-05-6.mol

Synonyms:(R)-Rivastigmine;415973-05-6;Rivastigmine, (R)-;(R)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate;SDZ-212712;Z25UDQ15MV;[3-[(1R)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate;Carbamic acid, N-ethyl-N-methyl-, 3-((1R)-1-(dimethylamino)ethyl)phenyl ester;3-[(1R)-1-(DIMETHYLAMINO)ETHYL]PHENYL N-ETHYL-N-METHYLCARBAMATE;UNII-Z25UDQ15MV;RIVASTIGMINE TARTRATE R-ISOMER;Rivastigmine specified impurity D [EP];Rivastigmine hydrogen tartrate specified impurity D [EP];SCHEMBL13841811;DTXSID90194422;RIVASTIGMINE IMPURITY D [EP IMPURITY];RIVASTIGMINE TARTRATE R-ISOMER [USP-RS];EN300-18983660;J-502343;Q27294895;(R)-3-(1-(Dimethylamino)ethyl)phenylethyl(methyl)carbamate;RIVASTIGMINE HYDROGEN TARTRATE IMPURITY D [EP IMPURITY];(S)-1-(3-((ethyl(methyl)carbamoyl)oxy)phenyl)-N,N-dimethylethanamine

Suppliers and Price of (R)-Rivastigmine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Rivastigmine
50mg
$ 1105.00

Sigma-Aldrich
Rivastigmine tartrate R-isomer
20mg
$ 1260.00

Sigma-Aldrich
Rivastigmine impurity D European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Rivastigmine impurity D European Pharmacopoeia (EP) Reference Standard
y0001515
$ 190.00

Crysdot
(R)-3-(1-(Dimethylamino)ethyl)phenylethyl(methyl)carbamate 95%
1g
$ 880.00

Alichem
(R)-3-(1-(Dimethylamino)ethyl)phenylethyl(methyl)carbamate
1g
$ 728.28

Total 14 raw suppliers

Chemical Property of (R)-Rivastigmine

Chemical Property:

Boiling Point:316.2±34.0 °C(Predicted)
PKA:8.62±0.50(Predicted)
PSA：32.78000
Density:1.038±0.06 g/cm3(Predicted)
LogP:2.75970
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:250.168127949
Heavy Atom Count:18
Complexity:269

Purity/Quality:

99% ^*data from raw suppliers

(R)-Rivastigmine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
Isomeric SMILES:CCN(C)C(=O)OC1=CC=CC(=C1)[C@@H](C)N(C)C

Technology Process of (R)-Rivastigmine

There total 86 articles about (R)-Rivastigmine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1176026-49-5
(S)-3-(1-aminoethyl)phenyl ethyl(methyl)carbamate

: 123441-03-2,415973-05-6
rivastigmin

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; water; at 20 ℃; for 16.5h;
DOI:10.1016/j.tet.2012.06.031

Reference yield: 98.0%

: 42252-34-6
N-ethyl-N-methylcarbamoyl chloride

: 139306-10-8
(S)-3-(1-dimethylaminoethyl)phenol

: 123441-03-2,415973-05-6
rivastigmin

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201504052