Acetic acid, (hydroxymethylphosphinyl)-

Base Information

• Chemical Name: Acetic acid, (hydroxymethylphosphinyl)-
• CAS No.: 72651-25-3
• Molecular Formula: C3H6O4P+
• Molecular Weight: 137.0506
• DSSTox Substance ID: DTXSID70993495
• Wikidata: Q82984180
• Mol file: 72651-25-3.mol

Synonyms:Acetic acid, (hydroxymethylphosphinyl)-;carboxymethyl-(hydroxymethyl)-oxophosphanium;SCHEMBL11509838;DTXSID70993495;(Carboxymethyl)(hydroxymethyl)oxophosphanium

Chemical Property of Acetic acid, (hydroxymethylphosphinyl)-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 108.74000
• Density: g/cm³
• LogP: -0.15180
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 137.00037067
• Heavy Atom Count: 8
• Complexity: 110

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

2-[HYDROXY(METHYL)PHOSPHORYL]ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)O)[P+](=O)CO

Technology Process of Acetic acid, (hydroxymethylphosphinyl)-

There total 2 articles about Acetic acid, (hydroxymethylphosphinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-butyllithium (109-72-8,29786-93-4) + dimethylphosphinic acid, phenylmethyl ester (72651-23-1) → [methyl(phenylmethoxy)phosphinyl]acetic acid (72651-24-2) + (hydroxymethylphosphinyl)acetic acid (72651-25-3)

Guidance literature:

With diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane;

Reference yield:

Methyl-(ethoxymethyl-phosphinyl)-acetat → (hydroxymethylphosphinyl)acetic acid (72651-25-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00215a008

upstream raw materials:

n-butyllithium

dimethylphosphinic acid, phenylmethyl ester