4-[(4-Methylphenyl)carbonyl]piperidine hydrochloride

Base Information

Chemical Name:4-[(4-Methylphenyl)carbonyl]piperidine hydrochloride
CAS No.:42060-84-4
Molecular Formula:C13H17NO.ClH
Molecular Weight:239.745
Hs Code.:
DSSTox Substance ID:DTXSID20372392
ChEMBL ID:CHEMBL1321935

Synonyms:42060-84-4;4-(4-methylbenzoyl)piperidine hydrochloride;4-[(4-methylphenyl)carbonyl]piperidine hydrochloride;(4-methylphenyl)-piperidin-4-ylmethanone;hydrochloride;MLS000074037;(piperidin-4-yl)(p-tolyl)methanone hydrochloride;SCHEMBL2366330;CHEMBL1321935;DTXSID20372392;Piperidin-4-yl-p-tolyl-methanone;IQGHJDJWYVPSGM-UHFFFAOYSA-N;SMR000006301;4-(4-methylbenzoyl)piperidinehydrochloride;CS-0250382;EN300-50628;(piperidin-4-yl) (p-tolyl)methanone hydrochloride;(4-methylphenyl)piperidin-4-ylmethanone hydrochloride;(4-methylphenyl)(piperidin-4-yl)methanone hydrochloride;Z752370820

Suppliers and Price of 4-[(4-Methylphenyl)carbonyl]piperidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-[(4-Methylphenyl)carbonyl]piperidine hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:239.1076919
Heavy Atom Count:16
Complexity:213

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)C2CCNCC2.Cl

Technology Process of 4-[(4-Methylphenyl)carbonyl]piperidine hydrochloride

There total 3 articles about 4-[(4-Methylphenyl)carbonyl]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887352-19-4
1-(4-(4-methylbenzoyl)piperidin-1-yl)ethanone

: 42060-84-4
(piperidin-4-yl)(p-tolyl)methanone hydrochloride

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; for 10h; Reflux;
DOI:10.1016/j.bmcl.2015.09.072

Reference yield:

: 59084-16-1
1-acetylpiperidine-4-carbonyl chloride

: 42060-84-4
(piperidin-4-yl)(p-tolyl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 65 °C

2: hydrogenchloride; water / tetrahydrofuran / 10 h / Reflux

With hydrogenchloride; aluminum (III) chloride; water; In tetrahydrofuran; 1,2-dichloro-ethane; 1: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmcl.2015.09.072

Reference yield:

: 498-94-2
isonipecotic acid

: 42060-84-4
(piperidin-4-yl)(p-tolyl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 2 h / 140 °C

2: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4 h / 0 - 60 °C

3: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 65 °C

4: hydrogenchloride; water / tetrahydrofuran / 10 h / Reflux

With pyridine; hydrogenchloride; aluminum (III) chloride; thionyl chloride; water; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dichloro-ethane; 3: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmcl.2015.09.072