Chemical Property of 3-(Methyl(3-(4-(phenylmethyl)phenoxy)propyl)amino)propanoic acid
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:163-165°C
- Boiling Point:499.7oC at 760 mmHg
- Flash Point:256.01oC
- PSA：49.77000
- Density:1.115g/cm3
- LogP:4.25480
- Storage Temp.:Desiccate at +4°C
- Solubility.:DMSO: >5mg/mL
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:10
- Exact Mass:363.1601214
- Heavy Atom Count:25
- Complexity:347
- Purity/Quality:
-
99%, *data from raw suppliers
SC-57461A *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN(CCCOC1=CC=C(C=C1)CC2=CC=CC=C2)CCC(=O)O.Cl
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Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.
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Uses
SC 57461A is a potent and selective inhibitor of LTA4. A potent and selective orally active leukotriene A4 hydrolase inhibitor.
