2-tert-Butyl-4-Methylthiazole-5-carboxylic acid, 98%

Base Information

• Chemical Name: 2-tert-Butyl-4-Methylthiazole-5-carboxylic acid, 98%
• CAS No.: 427896-41-1
• Molecular Formula: C₉H₁₃NO₂S
• Molecular Weight: 199.274
• Mol file: 427896-41-1.mol

Synonyms:

Chemical Property of 2-tert-Butyl-4-Methylthiazole-5-carboxylic acid, 98%

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-tert-Butyl-4-methyl-1,3-thiazole-5-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-Butyl-4-Methylthiazole-5-carboxylic acid, 98%

There total 3 articles about 2-tert-Butyl-4-Methylthiazole-5-carboxylic acid, 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-(tert-butyl)-4-methylthiazole-5-carboxylate → 2-(tert-butyl)-4-methylthiazole-5-carboxylic acid (427896-41-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 4h; Reflux;

DOI:10.1016/j.ejmech.2019.07.002

Reference yield:

2,2-dimethylpropanethioamide (630-22-8) → 2-(tert-butyl)-4-methylthiazole-5-carboxylic acid (427896-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Inert atmosphere; Reflux

2: sodium hydroxide / ethanol; water / 4 h / Reflux

With sodium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2019.07.002

Reference yield:

2,2-dimethylpropionamide (754-10-9) → 2-(tert-butyl)-4-methylthiazole-5-carboxylic acid (427896-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Lawessons reagent / tetrahydrofuran / 4 h / Reflux; Inert atmosphere

2: ethanol / 24 h / Inert atmosphere; Reflux

3: sodium hydroxide / ethanol; water / 4 h / Reflux

With Lawessons reagent; sodium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.ejmech.2019.07.002

upstream raw materials:

2,2-dimethylpropanethioamide

2,2-dimethylpropionamide