2-Propen-1-amine, 3-(4-chlorophenyl)-N,N-dimethyl-, (E)-

Base Information

Chemical Name:2-Propen-1-amine, 3-(4-chlorophenyl)-N,N-dimethyl-, (E)-
CAS No.:42817-51-6
Molecular Formula:C11H14ClN
Molecular Weight:195.692
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propen-1-amine, 3-(4-chlorophenyl)-N,N-dimethyl-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2-Propen-1-amine, 3-(4-chlorophenyl)-N,N-dimethyl-, (E)-

There total 1 articles about 2-Propen-1-amine, 3-(4-chlorophenyl)-N,N-dimethyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42817-51-6
p-Chloro-N,N-dimethylcinnamylamine

Guidance literature:: <2-Dimethylamino-aethyl>-triphenyl-phosphonium-bromid (11)-hydrobromid, 1)BuLi in Hexan, 2)4-Chlor-benzaldehyd in THF;
DOI:10.1002/hlca.19780610519

Reference yield: 93.0%

: 42817-51-6
p-Chloro-N,N-dimethylcinnamylamine

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: (R,E)-ethyl 1-(3-(4-chlorophenyl)allyl)-2-oxocyclopentanecarboxylate

Guidance literature:: With palladium diacetate; O-(tert-butyldimethylsilyloxy)-L-threonine; P(p-C₆H₄F)3; In toluene; at 90 ℃; for 5h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/acs.joc.9b02282

Reference yield:

: 42817-51-6
p-Chloro-N,N-dimethylcinnamylamine

: 132-22-9
Chlorpheniramine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / HRh(CO)(PPh₃)3 / benzene / 24 h / 80 °C / 76000 Torr

2: NH₂OH

3: 92 percent / CS₂, n-Bu₄N⁽¹⁺⁾*HSO₄^(1-), 15percent aq. NaOH / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 75 percent / (η⁵-cyclopentadienyl)<(1,5-η)-cyclopentadienyl>cobalt / toluene / 36 h / 140 °C / 10640 Torr

With carbon disulfide; sodium hydroxide; hydrogen; hydroxylamine; tetra(n-butyl)ammonium hydrogensulfate; carbonylhydridetris(triphenylphosphine)rhodium(I); (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In dichloromethane; toluene; benzene;
DOI:10.1021/jo00102a044