1-(4-Methoxyphenoxy)-2-propanol

Base Information

• Chemical Name: 1-(4-Methoxyphenoxy)-2-propanol
• CAS No.: 42900-54-9
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID20444306
• Nikkaji Number: J383.024A
• ChEMBL ID: CHEMBL77476
• Mol file: 42900-54-9.mol

Synonyms:1-(4-Methoxyphenoxy)-2-propanol;42900-54-9;1-(4-methoxyphenoxy)propan-2-ol;4-(2-Hydroxypropoxy)anisole;CHEMBL77476;1-p-methoxyphenoxy-2-propanol;SCHEMBL1496625;1(4-Methoxyphenoxy)-2-propanol;DTXSID20444306;VRJJZESAMSRBTH-UHFFFAOYSA-N;MFCD00191541;AKOS009159194;CS-0323204;FT-0639812;M1062;D91437;A826058

Chemical Property of 1-(4-Methoxyphenoxy)-2-propanol

Chemical Property:

• Melting Point: 63oC
• Boiling Point: 140oC / 8mmHg
• Flash Point: 135.519oC
• PSA: 38.69000
• Density: 1.082g/cm3
• LogP: 1.45480
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 130

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Methoxyphenoxy)-2-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(COC1=CC=C(C=C1)OC)O

Technology Process of 1-(4-Methoxyphenoxy)-2-propanol

There total 4 articles about 1-(4-Methoxyphenoxy)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-epoxypropyl p-methoxyphenyl ether (2211-94-1,26744-15-0) → 1-(p-Methoxyphenoxy)-2-propanol (42900-54-9)

Guidance literature:

With morpholine-borane; boron trifluoride diethyl etherate; In diethyl ether; for 2h; Product distribution; Ambient temperature;

DOI:10.1021/jo00191a036

Reference yield:

sodium 4-methoxyphenolate (1122-95-8) + 1-Chloro-2-propanol (127-00-4) → 1-(p-Methoxyphenoxy)-2-propanol (42900-54-9)

Guidance literature:

With ethanol;

DOI:10.1021/ja01153a033

Reference yield:

4-methoxy-phenol (150-76-5) + methyloxirane (75-56-9,16033-71-9) → 1-(p-Methoxyphenoxy)-2-propanol (42900-54-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jm00337a015

upstream raw materials:

sodium 4-methoxyphenolate

1-Chloro-2-propanol

2,3-epoxypropyl p-methoxyphenyl ether

4-methoxy-phenol

Downstream raw materials:

2-Brom-1-(4-methoxy-phenoxy)-propan

1-(4-Methoxy-phenoxy)-2-hydrazino-propan

1-[2-(benzyloxy)propoxy]-4-methoxybenzene

Refernces

• 1、 Schvartzapel, Andrea J.,Zhong, Li,Docampo, Roberto,Rodriguez, Juan B.,Gros, Eduardo G.. "Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)". . p. 2314 - 2322. Retrieved 2007/10/03.
• 2、 DRAIN,HOWES,LAZARE,SALAMAN,SHADBOLT,WILLIAMS. "MONOAMINE OXIDASE INHIBITORS. THE SYNTHESIS AND EVALUATION OF A SERIES". . p. 63 - 69. Retrieved 2007/10/05.