3-Iodo-alpha-methyl-l-tyrosine

Base Information

• Chemical Name: 3-Iodo-alpha-methyl-l-tyrosine
• CAS No.: 4298-17-3
• Molecular Formula: C₁₀H₁₂INO₃
• Molecular Weight: 321.115
• UNII: NZ6Q8MU40A
• DSSTox Substance ID: DTXSID70570987
• Nikkaji Number: J1.530.967I
• Wikidata: Q27285117
• Mol file: 4298-17-3.mol

Synonyms:3-iodo-alpha-methyl-l-tyrosine;4298-17-3;m-Iodo-alpha-methyl-L-tyrosine;UNII-NZ6Q8MU40A;NZ6Q8MU40A;Tyrosine, 3-iodo-alpha-methyl-,;L- L-3-iodo-alpha-methyltyrosine;L-Tyrosine, 3-iodo-alpha-methyl-;(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)-2-methylpropanoic acid;3-IAMT;SCHEMBL6340559;DTXSID70570987;3-IODO-.ALPHA.-METHYL-L-TYROSINE;M-IODO-.ALPHA.-METHYL-L-TYROSINE;L- L-3-IODO-.ALPHA.-METHYLTYROSINE;L-TYROSINE, 3-IODO-.ALPHA.-METHYL-;TYROSINE, 3-IODO-.ALPHA.-METHYL-, L-;Q27285117;(S)-2-Amino-3-(4-hydroxy-3-iodophenyl)-2-methylpropanoic acid

Chemical Property of 3-Iodo-alpha-methyl-l-tyrosine

Chemical Property:

• PSA: 83.55000
• LogP: 2.04160
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 320.98619
• Heavy Atom Count: 15
• Complexity: 249

Purity/Quality:

3-IODO-ALPHA-METHYL-PARA-TYROSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1)O)I)(C(=O)O)N
• Isomeric SMILES: C[C@](CC1=CC(=C(C=C1)O)I)(C(=O)O)N

Technology Process of 3-Iodo-alpha-methyl-l-tyrosine

There total 3 articles about 3-Iodo-alpha-methyl-l-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

α-methyltyrosine (5380-13-2) → L-3-iodo-α-methyltyrosine (14684-02-7,4298-17-3)

Guidance literature:

With chloroamine-T; sodium iodide; In water; for 0.0833333h;

DOI:10.1002/(SICI)1099-1344(199804)41:4<255::AID-JLCR89>3.3.CO;2-F

Reference yield:

L-methyltyrosine (672-87-7,5380-13-2) → 3-iodo-α-methyl-L-tyrosine (14684-02-7,4298-17-3)

Guidance literature:

With ammonium hydroxide; iodine; potassium iodide;

DOI:10.1021/jm00318a005

Reference yield:

2-amino-3-(4-hydroxy-phenyl)-2-methyl-propionic acid (658-48-0,5380-13-2) → 3-iodo-α-methyl-DL-tyrosine (779-96-4,14684-02-7,4298-17-3)

Guidance literature:

With ammonium hydroxide; iodine; potassium iodide;

DOI:10.1021/jm00318a005

upstream raw materials:

2-amino-3-(4-hydroxy-phenyl)-2-methyl-propionic acid

L-methyltyrosine

α-methyltyrosine