Carbamic acid, [[4-[[[[(2S)-1-[(2R)-[3-chloro-5-(difluoromethoxy)phenyl]hydroxyacetyl]-2- azetidinyl]carbonyl]amino]methyl]-3,5-difluorophenyl]iminomethyl]-, 2-(trimethylsilyl)ethyl ester

Base Information

Chemical Name:Carbamic acid, [[4-[[[[(2S)-1-[(2R)-[3-chloro-5-(difluoromethoxy)phenyl]hydroxyacetyl]-2- azetidinyl]carbonyl]amino]methyl]-3,5-difluorophenyl]iminomethyl]-, 2-(trimethylsilyl)ethyl ester
CAS No.:433939-99-2
Molecular Formula:C27H31ClF4N4O6Si
Molecular Weight:647.098
Hs Code.:

Carbamic acid,
[[4-[[[[(2S)-1-[(2R)-[3-chloro-5-(difluoromethoxy)phenyl]hydroxyacetyl]-2-
azetidinyl]carbonyl]amino]methyl]-3,5-difluorophenyl]iminomethyl]-,
2-(trimethylsilyl)ethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [[4-[[[[(2S)-1-[(2R)-[3-chloro-5-(difluoromethoxy)phenyl]hydroxyacetyl]-2- azetidinyl]carbonyl]amino]methyl]-3,5-difluorophenyl]iminomethyl]-, 2-(trimethylsilyl)ethyl ester

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Technology Process of Carbamic acid, [[4-[[[[(2S)-1-[(2R)-[3-chloro-5-(difluoromethoxy)phenyl]hydroxyacetyl]-2- azetidinyl]carbonyl]amino]methyl]-3,5-difluorophenyl]iminomethyl]-, 2-(trimethylsilyl)ethyl ester

There total 4 articles about Carbamic acid, [[4-[[[[(2S)-1-[(2R)-[3-chloro-5-(difluoromethoxy)phenyl]hydroxyacetyl]-2- azetidinyl]carbonyl]amino]methyl]-3,5-difluorophenyl]iminomethyl]-, 2-(trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 433938-42-2
(2R)-[3-chloro-5-(difluoromethoxy)-phenyl](hydroxy)acetic acid

: C₁₈H₂₆F₂N₄O₃Si

: 433939-99-2
Ph(3-Cl)(5-OCHF₂)-(R)-CH(OH)C(O)-Aze-Pab(2,6-diF)(Teoc)

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 2h;

Reference yield: 60.0%

: 433938-42-2
(2R)-[3-chloro-5-(difluoromethoxy)-phenyl](hydroxy)acetic acid

: 433939-98-1
Boc-Aze-Pab(2,6-diF)(Teoc)

: 433939-99-2
Ph(3-Cl)(5-OCHF₂)-(R)CH(OH)C(O)-Aze-Pab(2,6-diF)(Teoc)

Guidance literature:: Boc-Aze-Pab(2,6-diF)(Teoc); With hydrogenchloride; In ethyl acetate; for 0.166667h;

(2R)-[3-chloro-5-(difluoromethoxy)-phenyl](hydroxy)acetic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 2h;

Reference yield: 60.0%

: 433938-42-2
(2R)-[3-chloro-5-(difluoromethoxy)-phenyl](hydroxy)acetic acid

: 433939-98-1
Boc-Aze-Pab(2,6-diF)(Teoc)

: 433939-99-2
Ph(3-Cl)(5-OCHF₂)-(R)-CH(OH)C(O)-Aze-Pab(2,6-diF)(Teoc)

Guidance literature:: Boc-Aze-Pab(2,6-diF)(Teoc); With hydrogenchloride; In ethyl acetate; for 0.166667h;

(2R)-[3-chloro-5-(difluoromethoxy)-phenyl](hydroxy)acetic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); ethyl acetate; for 2h;