3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol

Base Information

Chemical Name:3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol
CAS No.:437756-52-0
Molecular Formula:C29H31NO3
Molecular Weight:441.57
Hs Code.:

Synonyms:3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol;CHF 4056;CHF-4056;CHF4056

Suppliers and Price of 3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol

Chemical Property:

XLogP3:5.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:441.23039385
Heavy Atom Count:33
Complexity:629

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)CCOC2=CC=C(C=C2)CC3=C(COC4=C3C=CC(=C4)O)C5=CC=CC=C5

Technology Process of 3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol

There total 12 articles about 3-phenyl-4-((4-(2-(1-piperidinyl)ethoxy)phenyl)methyl)-2H-1-benzopyran-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: rac-3-phenyl-4-E-(4-(2-(N-piperidinyl)ethoxy)benzyliden)-7-hydroxychromane hydrochloride

: 437756-52-0
3-phenyl-4-(4-(2-(N-piperidinyl)ethoxy)benzyl)-7-hydroxychrom-3-ene

Guidance literature:: rac-3-phenyl-4-E-(4-(2-(N-piperidinyl)ethoxy)benzyliden)-7-hydroxychromane hydrochloride; With hydrogenchloride; In water; acetonitrile; at 80 ℃; for 0.25h;

With potassium carbonate;

Reference yield: 70.0%

: 444643-82-7
3,4-dihydro-3-phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]-2H-1-benzopyran-4,7-diol

: 437756-52-0
3-phenyl-4-(4-(2-(N-piperidinyl)ethoxy)benzyl)-7-hydroxychrom-3-ene

Guidance literature:: With hydrogenchloride; In acetonitrile; Heating;
DOI:10.1016/j.bmc.2004.05.015

Reference yield:

: 444643-79-2
2,2-dimethyl-propanoic acid 3,4-dihydro-4-hydroxy-3-phenyl-4-[[4-(phenylmethoxy)phenyl]methyl]-2H-1-benzopyran-7-yl ester

: 437756-52-0
3-phenyl-4-(4-(2-(N-piperidinyl)ethoxy)benzyl)-7-hydroxychrom-3-ene

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethyl acetate; H₂O / 20 °C / 2585.74 Torr

2: K₂CO₃ / acetone / Heating

3: 90 percent / K₂CO₃ / methanol / 20 °C

4: 70 percent / HCl / acetonitrile / Heating

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1016/j.bmc.2004.05.015