Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(9-hydroxy-9H-fluoren-9-yl)carbonyl]-2-pyrrolidinyl ]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(9-hydroxy-9H-fluoren-9-yl)carbonyl]-2-pyrrolidinyl ]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:439117-98-3
Molecular Formula:C32H34ClN3O5
Molecular Weight:576.092
Hs Code.:

Carbamic acid,
[[4-chloro-2-[[[[(2S)-1-[(9-hydroxy-9H-fluoren-9-yl)carbonyl]-2-pyrrolidinyl
]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(9-hydroxy-9H-fluoren-9-yl)carbonyl]-2-pyrrolidinyl ]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(9-hydroxy-9H-fluoren-9-yl)carbonyl]-2-pyrrolidinyl ]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(9-hydroxy-9H-fluoren-9-yl)carbonyl]-2-pyrrolidinyl ]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 467-69-6
9-hydroxy-9-fluorene carboxylic acid

: 439117-44-9
(S)-tert-butyl 4-chloro-2-((pyrrolidine-2-carboxamido)methyl)benzylcarbamate

: 439117-98-3
9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; pH=6;
DOI:10.1021/jm049423s

Reference yield:

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 184005-77-4
N-(9-hydroxyfluorene-9-carboxyl)-L-proline

: 439116-15-1
2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamine

: 439117-98-3
9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide;

Reference yield:

: 71989-31-6
Fmoc-Pro-OH

: 439117-98-3
9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole hydrate / dimethylformamide / 2 h / pH 6

2: 90 percent / piperidine / dimethylformamide / 0.25 h

3: 90 percent / 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N,N-diisopropylethylamine / dimethylformamide / 24 h / 20 °C / pH 6

With piperidine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm049423s