Technology Process of Pentanal, 2-[[(4-methoxyphenyl)methoxy]methyl]-4-methyl-, (2S)-
There total 1 articles about Pentanal, 2-[[(4-methoxyphenyl)methoxy]methyl]-4-methyl-, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
n-hexyltriphenylphosphonium iodide;
With
potassium tert-butylate;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at 0 ℃;
for 0.5h;
(S)-2-(4-Methoxy-benzyloxymethyl)-4-methyl-pentanal;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at 20 ℃;
for 6h;
DOI:10.1016/S0957-4166(02)00009-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: KOt-Bu / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / 0 °C
1.2: 60 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 6 h / 20 °C
2.1: 80 percent / DDQ / CH2Cl2; H2O / 1 h / 20 °C
3.1: oxalyl chloride; DMSO / CH2Cl2 / 1 h / -78 °C
4.1: KOt-Bu / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / 0 °C
4.2: tetrahydrofuran; hexamethylphosphoric acid triamide / 6 h / 20 °C
With
oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;
1.2: cis-Wittig olefination / 3.1: Swern oxidation / 4.2: cis-Wittig olefination;
DOI:10.1016/S0957-4166(02)00009-5
