Chemical Property of 9H-Fluorene-2,7-dicarboxamide, 9-oxo-N,N'-bis(3-phenylpropyl)-
Chemical Property:
- PSA：82.25000
- LogP:6.77280
- XLogP3:6.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:10
- Exact Mass:502.22564282
- Heavy Atom Count:38
- Complexity:736
- Purity/Quality:
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Safty Information:
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- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)CCCNC(=O)C2=CC3=C(C=C2)C4=C(C3=O)C=C(C=C4)C(=O)NCCCC5=CC=CC=C5
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Description
GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM.1 Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia.2?It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3?and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. GPI-16552 synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells.5
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Uses
GPI 16552 is a a novel PARG inhibitor that ameliorates ischemic brain damage in rat.
