Technology Process of Acetic acid, [[1-(cyclohexylmethyl)-2-methyl-1H-benz[g]indol-4-yl]oxy]-,
methyl ester
There total 10 articles about Acetic acid, [[1-(cyclohexylmethyl)-2-methyl-1H-benz[g]indol-4-yl]oxy]-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 29h;
DOI:10.1021/jm0401309
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 91 percent / Cs2CO3 / 32 h / Heating
2.1: 93 percent / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
3.1: 92 percent / 4-methylmorpholine N-oxide; tetrapropylammonium perruthenate / CH2Cl2
4.1: 75 percent / NaOEt / diethyl ether / 22 h / 10 - 20 °C
5.1: 82 percent / toluene / 3 h / Heating
6.1: NaH / dimethylformamide / 0.5 h
6.2: 90 percent / dimethylformamide / 168 h / 20 °C
7.1: 94 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
8.1: 82 percent / PdCl2; NaBH4 / methanol; tetrahydrofuran / 1 h / 20 °C
9.1: BBr3 / CH2Cl2 / 1 h / 20 °C
10.1: 0.23 g / Cs2CO3 / dimethylformamide / 29 h / 20 °C
With
sodium tetrahydroborate; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; sodium ethanolate; boron tribromide; sodium hydride; caesium carbonate; 4-methylmorpholine N-oxide; palladium dichloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0401309
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 75 percent / NaOEt / diethyl ether / 22 h / 10 - 20 °C
2.1: 82 percent / toluene / 3 h / Heating
3.1: NaH / dimethylformamide / 0.5 h
3.2: 90 percent / dimethylformamide / 168 h / 20 °C
4.1: 94 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C
5.1: 82 percent / PdCl2; NaBH4 / methanol; tetrahydrofuran / 1 h / 20 °C
6.1: BBr3 / CH2Cl2 / 1 h / 20 °C
7.1: 0.23 g / Cs2CO3 / dimethylformamide / 29 h / 20 °C
With
sodium tetrahydroborate; lithium aluminium tetrahydride; sodium ethanolate; boron tribromide; sodium hydride; caesium carbonate; palladium dichloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0401309
