Inosine, 1-[[2-[[bis(phenylthio)phosphinyl]oxy]ethoxy]methyl]-8-chloro-2',3'-O-(1- methylethylidene)-, 5'-(N,N'-diphenylphosphorodiamidate)

Base Information

Chemical Name:Inosine, 1-[[2-[[bis(phenylthio)phosphinyl]oxy]ethoxy]methyl]-8-chloro-2',3'-O-(1- methylethylidene)-, 5'-(N,N'-diphenylphosphorodiamidate)
CAS No.:444989-18-8
Molecular Formula:C40H41ClN6O9P2S2
Molecular Weight:911.333
Hs Code.:

Inosine,
1-[[2-[[bis(phenylthio)phosphinyl]oxy]ethoxy]methyl]-8-chloro-2',3'-O-(1-
methylethylidene)-, 5'-(N,N'-diphenylphosphorodiamidate)

Synonyms:

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Chemical Property of Inosine, 1-[[2-[[bis(phenylthio)phosphinyl]oxy]ethoxy]methyl]-8-chloro-2',3'-O-(1- methylethylidene)-, 5'-(N,N'-diphenylphosphorodiamidate)

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Technology Process of Inosine, 1-[[2-[[bis(phenylthio)phosphinyl]oxy]ethoxy]methyl]-8-chloro-2',3'-O-(1- methylethylidene)-, 5'-(N,N'-diphenylphosphorodiamidate)

There total 5 articles about Inosine, 1-[[2-[[bis(phenylthio)phosphinyl]oxy]ethoxy]methyl]-8-chloro-2',3'-O-(1- methylethylidene)-, 5'-(N,N'-diphenylphosphorodiamidate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203249-43-8
5'-O-TBDMS-2',3'-O-isopropylidene-8-bromoinosine

: 444989-18-8
8-chloro-N¹-[[[bis(phenylthio)phosphoryl]oxy-ethoxy]methyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / DBU / CH₂Cl₂ / 0.5 h / 20 °C

2: 90 percent / TBAF / tetrahydrofuran / 6 h / 20 °C

3: 84.5 percent / tetrazole; pyridine / 48 h / 20 °C

4: 50 mg / CH₃ONa; MeOH / 20 °C

5: 44 mg / pyridine; tetrazole; triisopropylbenzenesulfonyl chloride / 24 h / 20 °C

With pyridine; 1H-tetrazole; methanol; triisopropylbenzenesulfonyl chloride; tetrabutyl ammonium fluoride; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm010530l

Reference yield:

: 273387-14-7
dithiophenoxyphosphoryl chloride

: 444989-17-7
C₂₈H₃₂BrN₆O₈P

: 444989-18-8
8-chloro-N¹-[[[bis(phenylthio)phosphoryl]oxy-ethoxy]methyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Guidance literature:: With pyridine; 1H-tetrazole; triisopropylbenzenesulfonyl chloride; at 20 ℃; for 24h;
DOI:10.1021/jm010530l

Reference yield:

: 444989-15-5
8-bromo-N¹-[(2-acetoxyethoxy)-methyl]-2',3'-O-isopropylideneinosine

: 444989-18-8
8-chloro-N¹-[[[bis(phenylthio)phosphoryl]oxy-ethoxy]methyl]-5'-O-(dianilinophosphoryl)-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 3 steps

1: 84.5 percent / tetrazole; pyridine / 48 h / 20 °C

2: 50 mg / CH₃ONa; MeOH / 20 °C

3: 44 mg / pyridine; tetrazole; triisopropylbenzenesulfonyl chloride / 24 h / 20 °C

With pyridine; 1H-tetrazole; methanol; triisopropylbenzenesulfonyl chloride; sodium methylate;
DOI:10.1021/jm010530l