Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl-

Base Information

Chemical Name:Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl-
CAS No.:445380-60-9
Molecular Formula:C20H17O3P
Molecular Weight:336.327
Hs Code.:
DSSTox Substance ID:DTXSID60476308
Nikkaji Number:J1.706.516E
Wikidata:Q82307426

Synonyms:Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl-;445380-60-9;6-diphenylphosphoryl-2,3-dihydro-1,4-benzodioxine;SCHEMBL6320147;DTXSID60476308;(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)diphenylphosphine oxide

Suppliers and Price of Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl-

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:336.09153140
Heavy Atom Count:24
Complexity:432

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC2=C(O1)C=CC(=C2)P(=O)(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl-

There total 4 articles about Phosphine oxide, (2,3-dihydro-1,4-benzodioxin-6-yl)diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 503269-72-5
(2,3-dihydro-1,4-benzodioxin-6-yl)diphenylphosphine

: 445380-60-9
(2,3-dihydro-1,4-benzodioxin-6-yl)phospane oxide

Guidance literature:: With dihydrogen peroxide; In methanol; water; at 40 ℃; for 1h;

Reference yield: 90.0%

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 52287-51-1
6-bromo-1,4-benzodioxane

: 445380-60-9
(2,3-dihydro-1,4-benzodioxin-6-yl)phospane oxide

Guidance literature:: 6-bromo-1,4-benzodioxane; With n-butyllithium; In tetrahydrofuran; at -70 ℃;

chloro-diphenylphosphine; at -70 - 20 ℃;

With dihydrogen peroxide; In methanol; at 0 ℃;
DOI:10.1016/S0040-4039(02)02637-0

Reference yield:

: 493-09-4
benzo-1,4-dioxane

: 445380-60-9
(2,3-dihydro-1,4-benzodioxin-6-yl)phospane oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / NBS / dimethylformamide / 24 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -70 - 0 °C

3.1: aq. H₂O₂ / methanol / 1 h / 20 °C

With N-Bromosuccinimide; n-butyllithium; dihydrogen peroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200200634