Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

Base Information

Chemical Name:Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester
CAS No.:452978-61-9
Molecular Formula:C37H40F3N4O8PS
Molecular Weight:788.782
Hs Code.:

Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-,
(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]
-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth
yl)propyl ester

Synonyms:

Suppliers and Price of Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

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Chemical Property of Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

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Technology Process of Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

There total 2 articles about Butanoic acid, 4-[[bis(2-propenyloxy)phosphinyl]oxy]-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329744-44-7
4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile

: 452978-61-9
(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 4-([bis(allyloxy)phosphoryl]oxy)butanoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 1268688-43-2
4-[[bis(allyloxy)phosphoryl]oxy]butylyl chloride

: 329744-44-7
4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile

: 452978-61-9
(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 4-([bis(allyloxy)phosphoryl]oxy)butanoate

Guidance literature:: 4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

4-[[bis(allyloxy)phosphoryl]oxy]butylyl chloride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;
DOI:10.1248/cpb.58.794

Reference yield: 64.0%

: 452978-61-9
(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 4-([bis(allyloxy)phosphoryl]oxy)butanoate

: disodium 4-([(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl]oxy)-4-oxobutyl phosphate

Guidance literature:: (2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 4-([bis(allyloxy)phosphoryl]oxy)butanoate; With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

In methanol; water;
DOI:10.1248/cpb.58.794