Benzoic acid, 2-[[[bis(2-propenyloxy)phosphinyl]oxy]methyl]-3-chloro-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

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Chemical Name:Benzoic acid, 2-[[[bis(2-propenyloxy)phosphinyl]oxy]methyl]-3-chloro-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester
CAS No.:452979-03-2
Molecular Formula:C41H39ClF3N4O8PS
Molecular Weight:871.271
Hs Code.:

Benzoic acid, 2-[[[bis(2-propenyloxy)phosphinyl]oxy]methyl]-3-chloro-,
(1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]
-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth
yl)propyl ester

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Chemical Property of Benzoic acid, 2-[[[bis(2-propenyloxy)phosphinyl]oxy]methyl]-3-chloro-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

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Technology Process of Benzoic acid, 2-[[[bis(2-propenyloxy)phosphinyl]oxy]methyl]-3-chloro-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester

There total 2 articles about Benzoic acid, 2-[[[bis(2-propenyloxy)phosphinyl]oxy]methyl]-3-chloro-, (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl] -1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmeth yl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1244713-16-3
2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-chlorobenzoyl chloride

: 329744-44-7
4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile

: 452979-03-2
(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 2-(([bis(allyloxy)phosphoryl]oxy)methyl)-3-chlorobenzoate

Guidance literature:: 4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-chlorobenzoyl chloride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;
DOI:10.1248/cpb.58.794

Reference yield:

: 452979-03-2
(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 2-(([bis(allyloxy)phosphoryl]oxy)methyl)-3-chlorobenzoate

Guidance literature:

Reference yield: 30.0%

: 452979-03-2
(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 2-(([bis(allyloxy)phosphoryl]oxy)methyl)-3-chlorobenzoate

: disodium 2-chloro-6-(([(2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl]oxy)carbonyl)benzyl phosphate

Guidance literature:: (2R,3R)-3-((trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)buta-1,3-dien-1-yl]-1,3-dioxan-5-yl)sulfanyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl 2-(([bis(allyloxy)phosphoryl]oxy)methyl)-3-chlorobenzoate; With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride; In dichloromethane; at 20 ℃; for 0.666667h;

With sodium hydrogencarbonate; In methanol; hexane; dichloromethane; water; at 20 ℃;
DOI:10.1248/cpb.58.794