5-Fluorouridine

Base Information

Chemical Name:5-Fluorouridine
CAS No.:316-46-1
Molecular Formula:C9H11FN2O6
Molecular Weight:262.195
Hs Code.:29349990
European Community (EC) Number:206-260-3
UNII:4K0M952561
DSSTox Substance ID:DTXSID4040397
Nikkaji Number:J36.572F
Wikidata:Q27073979
Metabolomics Workbench ID:52243
ChEMBL ID:CHEMBL54918
Mol file:316-46-1.mol

Synonyms:5-fluorouridine;5-fluorouridine, 18F-labeled

Suppliers and Price of 5-Fluorouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
5-Fluorouridine 99+%
1g
$ 206.00

TRC
5-FluoroUridine
10g
$ 365.00

TRC
5-FluoroUridine
1g
$ 100.00

TCI Chemical
5-Fluorouridine >98.0%(T)
5g
$ 120.00

TCI Chemical
5-Fluorouridine >98.0%(T)
1g
$ 40.00

SynQuest Laboratories
5-Fluorouridine 97%
25 g
$ 175.00

SynQuest Laboratories
5-Fluorouridine 97%
5 g
$ 55.00

SynQuest Laboratories
5-Fluorouridine 97%
1 g
$ 15.00

Sigma-Aldrich
5-Fluorouridine proapoptotic anitproliferative plant growth regulator
100mg
$ 94.70

Sigma-Aldrich
5-Fluorouridine proapoptotic anitproliferative plant growth regulator
250mg
$ 174.00

Total 66 raw suppliers

Chemical Property of 5-Fluorouridine

Chemical Property:

Appearance/Colour:White powder
Melting Point:182-184 °C
Refractive Index:18 ° (C=1, H2O)
PKA:7.63±0.10(Predicted)
PSA：124.78000
Density:1.77 g/cm³
LogP:-2.71280
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
Water Solubility.:soluble
XLogP3:-1.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:262.06011424
Heavy Atom Count:18
Complexity:414

Purity/Quality:

99% ^*data from raw suppliers

5-Fluorouridine 99+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 40-68-36/37/38
Safety Statements: 22-26-36/37-36/37/39-27-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)F
Isomeric SMILES:C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F
Recent ClinicalTrials:A Phase II Study of Envofolimab and BD0801 With/Without Chemotherapy in Patients With Advanced Solid Tumors
Description 5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.
Uses 5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750). Antihypertensive 5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.

Technology Process of 5-Fluorouridine

There total 41 articles about 5-Fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 58-96-8
uridine

: 316-46-1
5-fluorouridine

Guidance literature:: With caesium fluoroxysulphate; triethylamine; In methanol; water; Ambient temperature;
DOI:10.1039/c39830000563

Reference yield: 76.0%

: 51-21-8
5-fluorouracil

: 81100-62-1
7-methylguanosine hydroiodide

: 316-46-1
5-fluorouridine

Guidance literature:: With potassium dihydrogenphosphate; E_. coli purine nucleoside phosphorylase; E_. coli uridine phosphorylase; In aq. buffer; at 20 ℃; for 20h; pH=7.5; Enzymatic reaction;
DOI:10.1016/j.bbapap.2019.140292