Naphthalene, 2-[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Naphthalene, 2-[4-(trifluoromethyl)phenyl]-
• CAS No.: 460743-71-9
• Molecular Formula: C17H11F3
• Molecular Weight: 272.27
• DSSTox Substance ID: DTXSID70466255
• Nikkaji Number: J1.784.353B
• Mol file: 460743-71-9.mol

Synonyms:460743-71-9;Naphthalene, 2-[4-(trifluoromethyl)phenyl]-;SCHEMBL22389484;DTXSID70466255

Chemical Property of Naphthalene, 2-[4-(trifluoromethyl)phenyl]-

Chemical Property:

• XLogP3: 6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 272.08128484
• Heavy Atom Count: 20
• Complexity: 315

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)C3=CC=C(C=C3)C(F)(F)F

Technology Process of Naphthalene, 2-[4-(trifluoromethyl)phenyl]-

There total 36 articles about Naphthalene, 2-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromonaphthalene (580-13-2) + 4-trifluoromethylphenylboronic acid (128796-39-4) → 2-(4-(trifluoro-methyl)phenyl)naphthalene (460743-71-9)

Guidance literature:

With potassium carbonate; [PS-PEG-adppp-Pd(η³-C3H5)]Cl; In water; at 50 ℃; for 12h;

DOI:10.1021/ol0264298

Reference yield: 98.0%

C15H22AlF3 + 2-naphthyl diethylcarbamate (61912-14-9) → 2-(4-(trifluoro-methyl)phenyl)naphthalene (460743-71-9)

Guidance literature:

With bis(tricyclohexylphosphine)nickel(II) dichloride; In toluene; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.7b01058

Reference yield: 94.0%

2-Methoxynaphthalene (93-04-9) + 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane (501374-30-7) → 2-(4-(trifluoro-methyl)phenyl)naphthalene (460743-71-9)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; cesium fluoride; tricyclohexylphosphine; In toluene; at 120 ℃; for 12h;

DOI:10.1002/anie.200801447

upstream raw materials:

2-naphthyl triflate

2-bromonaphthalene

4-trifluoromethylphenylboronic acid

2-Methoxynaphthalene