1H-Indole, 3-[(2S)-1-[(1S,2R)-2,3-dihydro-2-hydroxy-7-methyl-1H-inden-1-yl]-1,2,5, 6-tetrahydro-4-(hydroxymethyl)-2-pyridinyl]-1-[(4-methylphenyl)sulfonyl]-

Base Information

Chemical Name:1H-Indole, 3-[(2S)-1-[(1S,2R)-2,3-dihydro-2-hydroxy-7-methyl-1H-inden-1-yl]-1,2,5, 6-tetrahydro-4-(hydroxymethyl)-2-pyridinyl]-1-[(4-methylphenyl)sulfonyl]-
CAS No.:461641-23-6
Molecular Formula:C31H32N2O4S
Molecular Weight:528.672
Hs Code.:

1H-Indole,
3-[(2S)-1-[(1S,2R)-2,3-dihydro-2-hydroxy-7-methyl-1H-inden-1-yl]-1,2,5,
6-tetrahydro-4-(hydroxymethyl)-2-pyridinyl]-1-[(4-methylphenyl)sulfonyl]-

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Chemical Property of 1H-Indole, 3-[(2S)-1-[(1S,2R)-2,3-dihydro-2-hydroxy-7-methyl-1H-inden-1-yl]-1,2,5, 6-tetrahydro-4-(hydroxymethyl)-2-pyridinyl]-1-[(4-methylphenyl)sulfonyl]-

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Technology Process of 1H-Indole, 3-[(2S)-1-[(1S,2R)-2,3-dihydro-2-hydroxy-7-methyl-1H-inden-1-yl]-1,2,5, 6-tetrahydro-4-(hydroxymethyl)-2-pyridinyl]-1-[(4-methylphenyl)sulfonyl]-

There total 16 articles about 1H-Indole, 3-[(2S)-1-[(1S,2R)-2,3-dihydro-2-hydroxy-7-methyl-1H-inden-1-yl]-1,2,5, 6-tetrahydro-4-(hydroxymethyl)-2-pyridinyl]-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 461641-22-5
5-methyl-4-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester

: 461641-23-6
1-{4-hydroxymethyl-6-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-7-methyl-indan-2-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.25h;
DOI:10.1021/jo049381f

Reference yield:

: (E)-1-(N-p-toluenesulfonyl-3-indolyl)-2-tributylstannylethene

: 461641-23-6
1-{4-hydroxymethyl-6-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-7-methyl-indan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 5.14 g / LiCl / Pd(PPh₃)4 / dimethylformamide / 0.5 h / 115 °C

2: 67 percent / MnO₂ / CH₂Cl₂ / 0.22 h / 20 °C

3: CHCl₃ / 12 h / 23 °C

4: 969 mg / LiAlH₄ / diethyl ether; tetrahydrofuran / 0 - 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja026464+

Reference yield:

: 461641-21-4
(E)-4-Hydroxy-2-{(E)-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinyl}-but-2-enoic acid ethyl ester

: 461641-23-6
1-{4-hydroxymethyl-6-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-7-methyl-indan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / MnO₂ / CH₂Cl₂ / 0.25 h / 20 °C

2: CHCl₃ / 12 h / 23 °C

3: 95 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.25 h / 0 - 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1021/jo049381f