Naphtho[2,3-b]furan-3-carboxylic acid, 4,9-dihydro-2-methyl-4,9-dioxo-

Base Information

• Chemical Name: Naphtho[2,3-b]furan-3-carboxylic acid, 4,9-dihydro-2-methyl-4,9-dioxo-
• CAS No.: 4655-54-3
• Molecular Formula: C14H8O5
• Molecular Weight: 256.215
• Mol file: 4655-54-3.mol

Synonyms:4-Carboxy-5-methyl-2,3-phthaloyl-furan;2-Methyl-4,9-dioxo-4,9-dihydro-naphtho[2,3-b]furan-3-carboxylic acid;

Chemical Property of Naphtho[2,3-b]furan-3-carboxylic acid, 4,9-dihydro-2-methyl-4,9-dioxo-

Chemical Property:

• Melting Point: 267 °C
• PSA: 84.58000
• LogP: 2.06160

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphtho[2,3-b]furan-3-carboxylic acid, 4,9-dihydro-2-methyl-4,9-dioxo-

There total 3 articles about Naphtho[2,3-b]furan-3-carboxylic acid, 4,9-dihydro-2-methyl-4,9-dioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate (4512-55-4) → 2-methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylic acid (4655-54-3)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

2,3-Dichloro-1,4-naphthoquinone (117-80-6) → 2-methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylic acid (4655-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 6 h / Reflux

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

→ 2-methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylic acid (4655-54-3)

Guidance literature:

4-Ethoxycarbonyl-5-methyl-2,3-phthaloyl-furan (5), sd. wss. HCl/Eg.;

upstream raw materials:

ethyl 2-methyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate

2,3-Dichloro-1,4-naphthoquinone