2(1H)-Pyridinone, 3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-4-[[(1S)-1-(phenylmethyl)-2- (triphenylmethoxy)ethyl]amino]-

Base Information

• Chemical Name: 2(1H)-Pyridinone, 3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-4-[[(1S)-1-(phenylmethyl)-2- (triphenylmethoxy)ethyl]amino]-
• CAS No.: 468741-09-5
• Molecular Formula: C41H35BrN4O2
• Molecular Weight: 695.658
• Mol file: 468741-09-5.mol

Synonyms:

Chemical Property of 2(1H)-Pyridinone, 3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-4-[[(1S)-1-(phenylmethyl)-2- (triphenylmethoxy)ethyl]amino]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(1H)-Pyridinone, 3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-4-[[(1S)-1-(phenylmethyl)-2- (triphenylmethoxy)ethyl]amino]-

There total 5 articles about 2(1H)-Pyridinone, 3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-4-[[(1S)-1-(phenylmethyl)-2- (triphenylmethoxy)ethyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S)-4-(1-benzyl-2-hydroxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one (468741-08-4) + trityl chloride (76-83-5) → (S)-4-(1-Benzyl-2-trityloxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one (468741-09-5)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; for 14h; Heating / reflux;

Reference yield:

5-bromo-3-methylbenzene-1,2-diamine (76153-06-5) → (S)-4-(1-Benzyl-2-trityloxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one (468741-09-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / methanol / 20 °C

2: 100 percent / HCl / dioxane; H₂O / 20 °C

3: 89 percent / Et₃N / dimethylformamide / 90 °C

4: 72 percent / Et₃N; DMAP / CH₂Cl₂

With hydrogenchloride; dmap; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.03.048

Reference yield:

C13H9BrIN3O (943634-36-4) → (S)-4-(1-Benzyl-2-trityloxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one (468741-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Et₃N / dimethylformamide / 90 °C

2: 72 percent / Et₃N; DMAP / CH₂Cl₂

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.03.048

upstream raw materials:

(S)-4-(1-benzyl-2-hydroxy-ethylamino)-3-(6-bromo-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-one

trityl chloride

6-bromo-2-(4-iodo-2-methoxy-pyridin-3-yl)-4-methyl-1H-benzimidazole

C₁₃H₉BrIN₃O

Downstream raw materials:

C₄₇H₄₀N₄O₂

C₄₇H₃₉FN₄O₂

C₄₈H₄₂N₄O₃