4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-5-METHYLOXAZOLE

Base Information

• Chemical Name: 4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-5-METHYLOXAZOLE
• CAS No.: 475481-96-0
• Molecular Formula: C11H9Cl2NO
• Molecular Weight: 242.10100
• Hs Code.: 2934999090
• Mol file: 475481-96-0.mol

Synonyms:4-(Trifluoromethoxy)benzyl Chloride;4-chloromethyl-1-trifluoromethoxybenzene;[4-(chloromethyl)phenoxy]trifluoromethane;4-chloromethyl-2-(2-chloro-phenyl)-5-methyl-oxazole;4-chloromethyl-5-methyl-2-(2-chloro-phenyl)-oxazole;

Chemical Property of 4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-5-METHYLOXAZOLE

Chemical Property:

• PSA: 26.03000
• LogP: 4.04220

Purity/Quality:

98%min ^*data from raw suppliers

4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-5-METHYLOXAZOLE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-5-METHYLOXAZOLE

There total 2 articles about 4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-5-METHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(2-chlorophenyl)-4,5-dimethyloxazole 3-oxide (897940-16-8) → 4-chloromethyl-5-methyl-2-(2-chloro-phenyl)-oxazole (475481-96-0)

Guidance literature:

With trichlorophosphate; In chloroform; Heating;

DOI:10.1016/j.bmcl.2006.05.007

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 4-chloromethyl-5-methyl-2-(2-chloro-phenyl)-oxazole (475481-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / HCl; AcOH / 0 °C

2: 55 percent / POCl₃ / CHCl₃ / Heating

With hydrogenchloride; acetic acid; trichlorophosphate; In chloroform;

DOI:10.1016/j.bmcl.2006.05.007

Reference yield: 74.0%

4-chloromethyl-5-methyl-2-(2-chloro-phenyl)-oxazole (475481-96-0) + isonipecotic acid (498-94-2) → 1-((2-(2-chlorolphenyl)-5-methyloxazol-4-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00561

upstream raw materials:

2-(2-chlorophenyl)-4,5-dimethyloxazole 3-oxide

2-chloro-benzaldehyde

Downstream raw materials:

(2S)-1-({1-[2-(2-Chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-cyclopropylamino}-acetyl)-pyrrolidine-2-carbonitrile

(2S)-1-({2-[2-(2-Chloro-phenyl)-5-methyl-oxazol-4-yl]-1,1-dimethyl-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile