Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-

Base Information

• Chemical Name: Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-
• CAS No.: 476681-59-1
• Molecular Formula: C15H8BrCl2N
• Molecular Weight: 353.045
• Mol file: 476681-59-1.mol

Synonyms:

Chemical Property of Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)-

There total 3 articles about Quinoline, 3-bromo-4-chloro-2-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-bromo-2-(4'-chlorophenyl)quinolin-4(1H)-one (502841-10-3,476681-53-5) → 4-chloro-2-(4-chlorophenyl)-3-bromoquinoline (476681-59-1)

Guidance literature:

With trichlorophosphate; for 2h; Heating;

Reference yield:

2-(4’-chlorophenyl)-4-quinolone (78396-10-8,6337-51-5) → 4-chloro-2-(4-chlorophenyl)-3-bromoquinoline (476681-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridinium tribromide / acetic acid / 3 h / 20 °C

2: POCl₃ / 2 h / Heating

With pyridinium hydrobromide perbromide; trichlorophosphate; In acetic acid;

DOI:10.1002/jhet.5570430203

Reference yield:

3-bromo-2-(4-chloro-phenyl)-1-methanesulfonyl-2,3-dihydro-1H-quinolin-4-one → 4-chloro-2-(4-chlorophenyl)-3-bromoquinoline (476681-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / DMSO / 5 h / 130 - 140 °C

2: 73 percent / POCl₃ / 2 h / Heating

With dimethyl sulfoxide; trichlorophosphate;

upstream raw materials:

3-bromo-2-(4'-chlorophenyl)quinolin-4(1H)-one

2-(4’-chlorophenyl)-4-quinolone

Downstream raw materials:

4-azido-3-bromo-2-(4-chlorophenyl)quinoline