5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide

Base Information

Chemical Name:5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide
CAS No.:128620-92-8
Molecular Formula:C₁₅H₂₄N₂O₅S₃
Molecular Weight:408.564
Hs Code.:
Mol file:128620-92-8.mol

Synonyms:5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide

Suppliers and Price of 5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide

Chemical Property:

Vapor Pressure:8.55E-13mmHg at 25°C
Boiling Point:565.2°C at 760 mmHg
Flash Point:295.6°C
PSA：155.95000
Density:1.334g/cm³
LogP:3.50270

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide

There total 15 articles about 5-(((methoxyethyl)((methoxyethoxy)ethyl)amino)methyl)thieno(2,3-b)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31486-85-8
2-Formylthieno<2,3-b>thiophene

: 128620-92-8
5-<<(methoxyethyl)<(methoxyethoxy)ethyl>amino>methyl>thieno<2,3-b>thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 4.08 g / p-toluenesulfonic acid, methyl orthoformate / toluene / 45 - 50 °C

3: concd. NH₄OH / acetone / 1.5 h

4: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

5: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d

6: 1.) NaCNBH₃, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min

With hydrogenchloride; ammonium hydroxide; 4 A molecular sieve; sodium cyanoborohydride; toluene-4-sulfonic acid; trimethyl orthoformate; In acetone; toluene;
DOI:10.1021/jm00110a008

Reference yield:

: 20969-37-3
methyl thieno[2,3-b]thiophene-2-carboxylate

: 128620-92-8
5-<<(methoxyethyl)<(methoxyethoxy)ethyl>amino>methyl>thieno<2,3-b>thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: LiAlH₄ / diethyl ether / 3 h / Ambient temperature

2: 13.10 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

3: 4.08 g / p-toluenesulfonic acid, methyl orthoformate / toluene / 45 - 50 °C

5: concd. NH₄OH / acetone / 1.5 h

6: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

7: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d

8: 1.) NaCNBH₃, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; 4 A molecular sieve; sodium cyanoborohydride; toluene-4-sulfonic acid; pyridinium chlorochromate; trimethyl orthoformate; In diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jm00110a008

Reference yield:

: 19685-82-6
methyl <(3-formylthiophene-2-yl)thio>acetate

: 128620-92-8
5-<<(methoxyethyl)<(methoxyethoxy)ethyl>amino>methyl>thieno<2,3-b>thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / methanol / 0.5 h

2: LiAlH₄ / diethyl ether / 3 h / Ambient temperature

3: 13.10 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

4: 4.08 g / p-toluenesulfonic acid, methyl orthoformate / toluene / 45 - 50 °C

6: concd. NH₄OH / acetone / 1.5 h

7: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

8: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d

9: 1.) NaCNBH₃, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; 4 A molecular sieve; DBN; sodium cyanoborohydride; toluene-4-sulfonic acid; pyridinium chlorochromate; trimethyl orthoformate; In methanol; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jm00110a008