Methyl 5-methoxy-1,3-oxazole-2-carboxylate

Base Information

• Chemical Name: Methyl 5-methoxy-1,3-oxazole-2-carboxylate
• CAS No.: 477870-14-7
• Molecular Formula: C6H7NO4
• Molecular Weight: 157.12400
• DSSTox Substance ID: DTXSID70363432
• Nikkaji Number: J2.690.943K
• Wikidata: Q82147126
• Mol file: 477870-14-7.mol

Synonyms:477870-14-7;methyl 5-methoxyoxazole-2-carboxylate;methyl 5-methoxy-1,3-oxazole-2-carboxylate;5-methoxyoxazole-2-carboxylic acid methyl ester;5-Methoxy-oxazole-2-carboxylic acid methyl ester;MFCD01814623;SCHEMBL4480497;DTXSID70363432;CUA87014;AC6206;AKOS005083519;SB37304;SY057668;CS-0217133;FT-0755084;1P-956;EN300-6890078;A914592;2-Oxazolecarboxylicacid,5-methoxy-,methylester(9CI);Z1198158653

Chemical Property of Methyl 5-methoxy-1,3-oxazole-2-carboxylate

Chemical Property:

• PSA: 61.56000
• LogP: 0.46980
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 157.03750770
• Heavy Atom Count: 11
• Complexity: 150

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxyoxazole-2-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=C(O1)C(=O)OC
• Uses: 5-Methoxyoxazole-2-carboxylic Acid Methyl Ester,is a oxazole-containing compound, that can be extensively used in medicinal chemistry. The oxazole group is a key element of a number of biologically active natural products.

Technology Process of Methyl 5-methoxy-1,3-oxazole-2-carboxylate

There total 2 articles about Methyl 5-methoxy-1,3-oxazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

dimethyloxalylglycine (89464-63-1) → methyl 5-methoxy-1,3-oxazole-2-carboxylate (477870-14-7)

Guidance literature:

With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2008.12.080

Reference yield: 22.0%

dimethyl cis-1-phthalimidoaziridine-2,3-dicarboxylate (1191037-76-9) + dimethylfumarate (624-49-7) → methyl 5-methoxy-1,3-oxazole-2-carboxylate (477870-14-7) + tetramethyl rel-(2R,3S,4S,5R)-1-phthalimidopyrrolidine-2,3,4,5-tetracarboxylate + tetramethyl rel-(2R,3R,4R,5R)-1-phthalimidopyrrolidine-2,3,4,5-tetracarboxylate

Guidance literature:

In benzene; at 220 ℃; for 3h;

DOI:10.1134/S1070428009080144

Reference yield: 11.0%

methyl 5-methoxy-1,3-oxazole-2-carboxylate (477870-14-7) → 5-methoxyoxazole-2-carboxylic acid (439109-82-7)

Guidance literature:

methyl 5-methoxy-1,3-oxazole-2-carboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; ethanol; pH=4;

upstream raw materials:

dimethyloxalylglycine

dimethyl cis-1-phthalimidoaziridine-2,3-dicarboxylate

dimethylfumarate

Downstream raw materials:

methyl 6-(4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

5-methoxyoxazole-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 477870-14-7 2-Oxazolecarboxylicacid,5-methoxy-,methylester(9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send