3-Amino-1,3-dihydro-5-(2-phenylethyl)-1-propyl-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:3-Amino-1,3-dihydro-5-(2-phenylethyl)-1-propyl-2H-1,4-benzodiazepin-2-one
CAS No.:478055-41-3
Molecular Formula:C20H23N3O
Molecular Weight:321.422
Hs Code.:
DSSTox Substance ID:DTXSID801147243
Mol file:478055-41-3.mol

Synonyms:SCHEMBL4700477;DTXSID801147243;3-Amino-1,3-dihydro-5-(2-phenylethyl)-1-propyl-2H-1,4-benzodiazepin-2-one;478055-41-3

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Amino-1,3-dihydro-5-(2-phenylethyl)-1-propyl-2H-1,4-benzodiazepin-2-one

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:321.184112366
Heavy Atom Count:24
Complexity:456

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN1C2=CC=CC=C2C(=NC(C1=O)N)CCC3=CC=CC=C3

Technology Process of 3-Amino-1,3-dihydro-5-(2-phenylethyl)-1-propyl-2H-1,4-benzodiazepin-2-one

There total 3 articles about 3-Amino-1,3-dihydro-5-(2-phenylethyl)-1-propyl-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026131-03-2
3-azido-5-phenethyl-1-propyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 478055-41-3
3-amino-5-(2-phenylethyl)-1-propyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water;
DOI:10.1021/jm034020y

Reference yield:

: 5-phenethyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 478055-41-3
3-amino-5-(2-phenylethyl)-1-propyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide

2.1: KHMDS / tetrahydrofuran

2.2: 2,4,6-triisopropylbenzenesulfonyl azide

2.3: AcOH

3.1: PPh₃ / tetrahydrofuran; H₂O

With potassium hexamethylsilazane; sodium hydride; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm034020y

Reference yield:

: 1027234-20-3
5-phenethyl-1-propyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 478055-41-3
3-amino-5-(2-phenylethyl)-1-propyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: KHMDS / tetrahydrofuran

1.2: 2,4,6-triisopropylbenzenesulfonyl azide

1.3: AcOH

2.1: PPh₃ / tetrahydrofuran; H₂O

With potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; water;
DOI:10.1021/jm034020y