2-Thiophenecarbonyl chloride, 4-bromo-5-methyl-

Base Information

Chemical Name:2-Thiophenecarbonyl chloride, 4-bromo-5-methyl-
CAS No.:478165-96-7
Molecular Formula:C₆H₄BrClOS
Molecular Weight:239.52
Hs Code.:

Synonyms:

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Chemical Property of 2-Thiophenecarbonyl chloride, 4-bromo-5-methyl-

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Technology Process of 2-Thiophenecarbonyl chloride, 4-bromo-5-methyl-

There total 3 articles about 2-Thiophenecarbonyl chloride, 4-bromo-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

: 29421-99-6
4-bromo-5-methyl-thiophene-2-carboxylic acid

: 478165-96-7
4-bromo-5-methylthiophene-2-carboxylic acid chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 1h;

Reference yield:

: 29421-73-6
3,5-dibromo-2-methylthiophene

: 478165-96-7
4-bromo-5-methylthiophene-2-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / n-BuLi / -78 °C

2: oxalyl chloride / CH₂Cl₂

With n-butyllithium; oxalyl dichloride; In dichloromethane;
DOI:10.1016/S0960-894X(01)00787-9

Reference yield:

: 1918-79-2
2-methylthiophene-5-carboxylic acid

: 478165-96-7
4-bromo-5-methylthiophene-2-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; iron(III) chloride; acetic acid / 5 h / 25 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 25 °C

With iron(III) chloride; oxalyl dichloride; bromine; acetic acid; N,N-dimethyl-formamide; In dichloromethane;