2-(2-Methylphenoxy)pyridine

Base Information

• Chemical Name: 2-(2-Methylphenoxy)pyridine
• CAS No.: 4783-78-2
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• DSSTox Substance ID: DTXSID301345969
• Nikkaji Number: J45.066I
• Wikidata: Q63409151
• Mol file: 4783-78-2.mol

Synonyms:2-Pyridyl o-tolyl ether;4783-78-2;2-(2-methylphenoxy)pyridine;pyridine,2-(2-methylphenoxy)-;Pyridine, (2-methylphenoxy)-;SCHEMBL4799563;DTXSID301345969;Q63409151

Chemical Property of 2-(2-Methylphenoxy)pyridine

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 185.084063974
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=CC=C1OC2=CC=CC=N2

Technology Process of 2-(2-Methylphenoxy)pyridine

There total 47 articles about 2-(2-Methylphenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-pyridine (109-04-6) + ortho-cresol (95-48-7,77504-84-8) → 2-(o-tolyloxy)pyridine (4783-78-2)

Guidance literature:

With potassium carbonate; 1-Butylimidazole; copper(l) chloride; In tetradecane; toluene; at 120 ℃; for 16h; Product distribution / selectivity;

Reference yield: 97.0%

2-iodopyridine (5029-67-4) + ortho-cresol (95-48-7,77504-84-8) → 2-(o-tolyloxy)pyridine (4783-78-2)

Guidance literature:

With 2-acetonylpyridine; caesium carbonate; copper(I) bromide; In dimethyl sulfoxide; at 80 ℃; for 10h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/jo9012157

Reference yield: 97.0%

1-propyl-2'-thiopyridine (26891-63-4) + 2-methylphenyl 2-naphthoate (88639-91-2) → 2-(o-tolyloxy)pyridine (4783-78-2) + naphthalene-2-yl(propyl)sulfane (75052-54-9)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); zinc; In toluene; at 150 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.1c04215

upstream raw materials:

2-bromo-pyridine

ortho-cresol

2-Pyridone

ortho-methylphenyl iodide

Downstream raw materials:

toluene