tert-butyl 3-carbaMoylazetidine-1-carboxylat

Base Information

• Chemical Name: tert-butyl 3-carbaMoylazetidine-1-carboxylat
• CAS No.: 486415-29-6
• Molecular Formula: C9H16N2O3
• Molecular Weight: 200.23500
• Hs Code.: 2933990090
• Mol file: 486415-29-6.mol

Synonyms:3-carbamoyl-azetidine-1-carboxylic acid tert-butyl ester;tert-butyl 3-(aminocarbonyl)azetidine-1-carboxylate;

Chemical Property of tert-butyl 3-carbaMoylazetidine-1-carboxylat

Chemical Property:

• Boiling Point: 355.9±31.0 °C(Predicted)
• PKA: 16.06±0.20(Predicted)
• PSA: 73.62000
• Density: 1.194±0.06 g/cm3(Predicted)
• LogP: 1.42620
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-azetidine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-carbaMoylazetidine-1-carboxylat

There total 4 articles about tert-butyl 3-carbaMoylazetidine-1-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid (142253-55-2) → tert-butyl 3-(aminocarbonyl)azetidine-1-carboxylate (486415-29-6)

Guidance literature:

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -20 - -10 ℃; for 0.25h;

With ammonium hydroxide; In tetrahydrofuran; at -20 - 20 ℃; for 1h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-(aminocarbonyl)azetidine-1-carboxylate (486415-29-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Et₃N

2.1: aq. NaOH

3.1: ClCOO-i-Bu; N-methylmorpholine

3.2: aq. NH₃

With 4-methyl-morpholine; sodium hydroxide; triethylamine; isobutyl chloroformate;

DOI:10.1016/S0960-894X(02)00002-1

Reference yield:

1-(tert-butyl) 3-ethyl azetidine-1,3-dicarboxylate → tert-butyl 3-(aminocarbonyl)azetidine-1-carboxylate (486415-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaOH

2.1: ClCOO-i-Bu; N-methylmorpholine

2.2: aq. NH₃

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate;

DOI:10.1016/S0960-894X(02)00002-1

upstream raw materials:

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 3-carbamothioylazetidine-1-carboxylate

tert-butyl 3-{1-[trans-4-(cyanomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}azetidine-1-carboxylate

azetidine-3-carboxamide

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