Phospholane, 1-phenyl-, 1-oxide

Base Information

• Chemical Name: Phospholane, 1-phenyl-, 1-oxide
• CAS No.: 4963-91-1
• Molecular Formula: C10H13OP
• Molecular Weight: 180.186
• Mol file: 4963-91-1.mol

Synonyms:1-oxo-1-phenylphospholane;1-phenylphospholane oxide;1-Phenyl-phospholan-1-oxid;1-Phenyl-phospholane 1-oxide;phenylphospholane oxide;-phenylphospholane 1-oxide;

Chemical Property of Phospholane, 1-phenyl-, 1-oxide

Chemical Property:

• Melting Point: 55 - 57 °C
• Boiling Point: 136-137 °C(Press: 0.3 Torr)
• PSA: 26.88000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 2.46880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phospholane, 1-phenyl-, 1-oxide

There total 16 articles about Phospholane, 1-phenyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phenyl-2-phospholene-1-oxide (703-03-7) → 1-phenylphospholane-1-oxide (4963-91-1)

Guidance literature:

With palladium 10% on activated carbon; In methanol; at 20 ℃; for 48h;

DOI:10.1002/chem.201301444

Reference yield: 99.0%

1-phenyl-3-phospholene 1-oxide (5186-73-2) → 1-phenylphospholane-1-oxide (4963-91-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/chem.201300546

Reference yield: 75.0%

1,4-dibromo-butane (110-52-1) + P,P-dichlorophenylphosphine oxide (824-72-6) → 1-phenylphospholane-1-oxide (4963-91-1)

Guidance literature:

1,4-dibromo-butane; With magnesium; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

P,P-dichlorophenylphosphine oxide; In tetrahydrofuran; at -78 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01476

upstream raw materials:

1-phenyl-3-phospholene 1-oxide

1-phenylphospholane

1,1-Diphenylphospholanium bromide

1-phenyl-2-phospholene-1-oxide

Downstream raw materials:

1-phenylphospholane-borane

trans-1-phenyl(2-hydroxy)phospholane oxide

Tributylphosphine oxide

(3-methylcyclohexa-1,4-dien-3-yl)phospholane oxide

Refernces

• 1、 Demchuk, Oleg M.,?wierczyńska, Wioletta,Dziuba, Kamil,Frynas, S?awomir,Flis, Anna,Pietrusiewicz, K. Micha?. "Raney-Ni reduction of phosphine sulfides". . p. 64 - 68. Retrieved 2016/12/24.
• 2、 Gregson, Aaron M.,Wales, Steven M.,Bailey, Stephen J.,Willis, Anthony C.,Keller, Paul A.. "Cyclic Phosphine Oxides and Phosphinamides from Di-Grignard Reagents and Phosphonic Dichlorides: Modular Access to Annulated Phospholanes". . p. 9774 - 9780. Retrieved 2015/10/12.