4-(Difluoromethyl)aniline

Base Information

Chemical Name:4-(Difluoromethyl)aniline
CAS No.:49658-26-6
Molecular Formula:C7H7F2N
Molecular Weight:143.136
Hs Code.:
DSSTox Substance ID:DTXSID50700745
Wikidata:Q82632200
Mol file:49658-26-6.mol

Synonyms:4-(DIFLUOROMETHYL)ANILINE;49658-26-6;Benzenamine, 4-(difluoromethyl)-;SCHEMBL11274191;DTXSID50700745;TQU0124;FRVATKJLVXRQHU-UHFFFAOYSA-N;MFCD18384829;AKOS006318245;SB85519;SY265648;EN300-104645;F80510

Suppliers and Price of 4-(Difluoromethyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Difluoromethyl)aniline
50mg
$ 1025.00

American Custom Chemicals Corporation
4-(DIFLUOROMETHYL)ANILINE 95.00%
5MG
$ 499.83

AK Scientific
4-(Difluoromethyl)aniline
5g
$ 1680.00

Acrotein
4-(Difluoromethyl)aniline 97%
5g
$ 846.15

Acrotein
4-(Difluoromethyl)aniline 97%
0.25g
$ 123.08

Total 16 raw suppliers

Chemical Property of 4-(Difluoromethyl)aniline

Chemical Property:

Boiling Point:219.7±30.0 °C(Predicted)
PKA:3.53±0.10(Predicted)
PSA：26.02000
Density:1.196±0.06 g/cm3(Predicted)
LogP:2.78760
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:143.05465555
Heavy Atom Count:10
Complexity:97.8

Purity/Quality:

98% purity ^*data from raw suppliers

4-(Difluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(F)F)N
Uses 4-(Difluoromethyl)-aniline is a reagent used for the synthesis of N-(1,3-thiazol-2-yl)ureas.

Technology Process of 4-(Difluoromethyl)aniline

There total 2 articles about 4-(Difluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29848-57-5
4-(difluoromethyl)nitrobenzene

: 49658-26-6
4-(difluoromethyl)aniline

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 49658-26-6
4-(difluoromethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / -70 °C

2: ammonium chloride; iron / tetrahydrofuran / 20 °C

With diethylamino-sulfur trifluoride; iron; ammonium chloride; In tetrahydrofuran; dichloromethane;

Reference yield: 37.9%

: 49658-26-6
4-(difluoromethyl)aniline

: 4-bromo-6-acetamido-1H-indole-2-carboxylic acid ethyl ester

: 4-((4-difluoromethylphenyl)amino)-6-acetylamino-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; at 110 ℃; for 1h; Microwave irradiation; Inert atmosphere;