Chemical Property of 2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazole
Chemical Property:
- Melting Point:257-258℃
- Boiling Point:415.3±38.0 °C(Predicted)
- PKA:11.52±0.10(Predicted)
- PSA：28.68000
- Density:1.102±0.06 g/cm3(Predicted)
- LogP:4.52740
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:4.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:2
- Exact Mass:250.146998583
- Heavy Atom Count:19
- Complexity:299
- Purity/Quality:
-
99%, *data from raw suppliers
ZLN005 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22-36
- Safety Statements:
26
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2
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Description
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.
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Uses
ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice.
