Glycine, N-[(4-fluorophenyl)methyl]-, ethyl ester

Base Information

Chemical Name:Glycine, N-[(4-fluorophenyl)methyl]-, ethyl ester
CAS No.:501653-63-0
Molecular Formula:C11H14FNO2
Molecular Weight:211.236
Hs Code.:

Synonyms:

Suppliers and Price of Glycine, N-[(4-fluorophenyl)methyl]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 7 raw suppliers

Chemical Property of Glycine, N-[(4-fluorophenyl)methyl]-, ethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(4-fluorophenyl)methyl]-, ethyl ester

There total 4 articles about Glycine, N-[(4-fluorophenyl)methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: ethyl 2-[N-ethoxycarbonyl-N-(4-fluorobenzyl)amino]acetate

: 501653-63-0
ethyl 2-[(4-fluorobenzyl)amino]acetate

Guidance literature:: ethyl 2-[N-ethoxycarbonyl-N-(4-fluorobenzyl)amino]acetate; With trimethylsilyl iodide; In chloroform; for 24h; Inert atmosphere; Reflux;

With methanol; In chloroform; for 3h; Inert atmosphere; Reflux;
DOI:10.1002/chem.201402514

Reference yield:

: diethyl 2-[(4-fluorobenzyl)amino]malonate hydrochloride

: 501653-63-0
ethyl 2-[(4-fluorobenzyl)amino]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride; methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: trimethylsilyl iodide / chloroform / 24 h / Inert atmosphere; Reflux

2.2: 3 h / Inert atmosphere; Reflux

With trimethylsilyl iodide; methyllithium; lithium chloride; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1002/chem.201402514

Reference yield:

: diethyl 2-[(4-fluorobenzyl)amino]malonate

: 501653-63-0
ethyl 2-[(4-fluorobenzyl)amino]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water

2.1: lithium chloride; methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: trimethylsilyl iodide / chloroform / 24 h / Inert atmosphere; Reflux

3.2: 3 h / Inert atmosphere; Reflux

With hydrogenchloride; trimethylsilyl iodide; methyllithium; lithium chloride; In tetrahydrofuran; diethyl ether; chloroform; water;
DOI:10.1002/chem.201402514