N-(2-nitrophenyl)pyridin-3-amine

Base Information

• Chemical Name: N-(2-nitrophenyl)pyridin-3-amine
• CAS No.: 5024-63-5
• Molecular Formula: C11H9N3O2
• Molecular Weight: 215.211
• DSSTox Substance ID: DTXSID90396424
• Wikidata: Q82197132
• ChEMBL ID: CHEMBL1327959
• Mol file: 5024-63-5.mol

Synonyms:N-(2-nitrophenyl)pyridin-3-amine;5024-63-5;3-Pyridinamine, N-(2-nitrophenyl)-;MLS001240997;SMR000841142;SCHEMBL4942857;CHEMBL1327959;BDBM64467;cid_3788918;DTXSID90396424;HMS2226A19;HMS3329J13;N-(2-nitrophenyl)-3-pyridinamine;(2-nitrophenyl)-(3-pyridyl)amine;3-pyridinamine,n-(2-nitrophenyl)-;AKOS027473703;EN300-7465646

Chemical Property of N-(2-nitrophenyl)pyridin-3-amine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 215.069476538
• Heavy Atom Count: 16
• Complexity: 242

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC2=CN=CC=C2)[N+](=O)[O-]

Technology Process of N-(2-nitrophenyl)pyridin-3-amine

There total 3 articles about N-(2-nitrophenyl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pyridin-3-ylamine (462-08-8) + o-nitroiodobenzene (609-73-4) → N-(2-nitrophenyl)pyridin-3-amine (5024-63-5)

Guidance literature:

With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 90 ℃; for 12h;

Reference yield: 76.0%

C13H11N3O4 (337931-56-3) → N-(2-nitrophenyl)pyridin-3-amine (5024-63-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃;

DOI:10.5012/bkcs.2013.34.2.394

Reference yield:

→ N-(2-nitrophenyl)pyridin-3-amine (5024-63-5)

Guidance literature:

3-Brompyridin, o-Nitroanilin, Cu/Na2CO3;

upstream raw materials:

C₁₃H₁₁N₃O₄

pyridin-3-ylamine

o-nitroiodobenzene

Downstream raw materials:

N-[3]pyridyl-o-phenylenediamine

Refernces

• 1、 -. "Fused phenanthridine derivatives substituted with aryl or heteroaryl, and organic electroluminescent device including the same". Paragraph 0373-0376. . Retrieved 2018/03/28.
• 2、 -. "ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE". Page/Page column 123. . Retrieved 2008/12/06.