Technology Process of Phosphonic acid, [2-ethyl-2-hydroxy-1-(phenylmethyl)butyl]-, methyl
phenylmethyl ester
There total 2 articles about Phosphonic acid, [2-ethyl-2-hydroxy-1-(phenylmethyl)butyl]-, methyl
phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 82 percent / Cs2CO3 / acetonitrile / 48 h / Heating
2.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.25 h / -78 °C
2.2: tetrahydrofuran; various solvent(s) / 1 h / -78 °C
2.3: 62 percent / NH4Cl / tetrahydrofuran; various solvent(s); H2O / -78 - 20 °C
With
n-butyllithium; caesium carbonate;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/jo026834c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: BHT; HCl / dioxane / 3 h / 50 °C
2.1: 82 percent / Cs2CO3 / acetonitrile / 48 h / Heating
3.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.25 h / -78 °C
3.2: tetrahydrofuran; various solvent(s) / 1 h / -78 °C
3.3: 62 percent / NH4Cl / tetrahydrofuran; various solvent(s); H2O / -78 - 20 °C
With
hydrogenchloride; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1021/jo026834c
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
at 20 ℃;
for 16h;
under 12929 Torr;
DOI:10.1021/jo026834c
