Technology Process of Phosphonic acid, [2-hydroxy-4-phenyl-1-(phenylmethyl)butyl]-,
1,1-dimethylethyl methyl ester
There total 3 articles about Phosphonic acid, [2-hydroxy-4-phenyl-1-(phenylmethyl)butyl]-,
1,1-dimethylethyl methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenethyl-phosphonic acid tert-butyl ester methyl ester;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.25h;
3-phenyl-propionaldehyde;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
ammonium chloride;
In
tetrahydrofuran; water;
at -78 - 20 ℃;
Further stages.;
DOI:10.1021/jo026834c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 62 percent / CH2Cl2; cyclohexane / 16 h
2.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.25 h / -78 °C
2.2: tetrahydrofuran; various solvent(s) / 1 h / -78 °C
2.3: 53 percent / NH4Cl / tetrahydrofuran; various solvent(s); H2O / -78 - 20 °C
With
n-butyllithium;
In
tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/jo026834c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: BHT; HCl / dioxane / 3 h / 50 °C
2.1: 62 percent / CH2Cl2; cyclohexane / 16 h
3.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.25 h / -78 °C
3.2: tetrahydrofuran; various solvent(s) / 1 h / -78 °C
3.3: 53 percent / NH4Cl / tetrahydrofuran; various solvent(s); H2O / -78 - 20 °C
With
hydrogenchloride; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane;
DOI:10.1021/jo026834c