tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
CAS No.:162540-84-3
Molecular Formula:C₃₇H₅₆N₄O₈
Molecular Weight:684.874
Hs Code.:
Mol file:162540-84-3.mol

tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Synonyms:12-Oxa-2,6,10-triazatetradecanoicacid,4,8-dihydroxy-13,13-dimethyl-11-oxo-3-[[4-[2-oxo-2-(1-piperidinyl)ethoxy]phenyl]methyl]-9-(phenylmethyl)-,1,1-dimethylethyl ester, [3S-(3R*,4S*,8S*,9R*)]-

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Chemical Property of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Chemical Property:

Vapor Pressure:8.75E-31mmHg at 25°C
Boiling Point:850.7°Cat760mmHg
Flash Point:468.3°C
PSA：165.67000
Density:1.171g/cm³
LogP:4.69870

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

There total 9 articles about tert-butyl [(2S,3R)-4-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-{4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}butyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 246047-29-0
((S)-3-Amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert-butyl ester

: {(S)-1-Oxiranyl-2-[4-(2-oxo-2-piperidin-1-yl-ethoxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester

: 162540-84-3
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 5h;
DOI:10.1021/jm950717a

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 162540-84-3
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

7: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, overnight

8: 28 percent / dimethylformamide / 5 h / 100 °C

With 4-methyl-morpholine; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: 1026977-99-0
C₂₆H₃₃NO₇

: 162540-84-3
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran; diethyl ether / 0 °C

2: HCl / dioxane / 0 °C

3: NaBH₄

4: KOH / ethanol

5: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

6: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, overnight

7: 28 percent / dimethylformamide / 5 h / 100 °C

With hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a