croalbinecine

Base Information

• Chemical Name: croalbinecine
• CAS No.: 41690-66-8
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.2096
• Mol file: 41690-66-8.mol

Synonyms:Croalbinecine;(+)-croalbinecine;coralbinecine;Croalbinecin;(1R,6R,7R,7aR)-7-Hydroxymethyl-hexahydro-pyrrolizine-1,6-diol;

Chemical Property of croalbinecine

Chemical Property:

• Vapor Pressure: 1.79E-05mmHg at 25°C
• Boiling Point: 325.3°Cat760mmHg
• Flash Point: 184.3°C
• PSA: 63.93000
• Density: 1.38g/cm³
• LogP: -1.65750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of croalbinecine

There total 8 articles about croalbinecine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Acetic acid (1R,2R,7R,7aR)-1-acetoxymethyl-7-hydroxy-hexahydro-pyrrolizin-2-yl ester (103478-44-0) → (+)-croalbinecine (41690-66-8)

Guidance literature:

With aluminium hydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(00)84337-3

Reference yield:

(1S,5S)-2-oxa-6-aza-6-((ethoxycarbonyl)methyl)bicyclo<3.3.0>octan-3-one (87332-79-4) → (+)-croalbinecine (41690-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium ethoxide / toluene / 4 h / Ambient temperature

2: H₂ / PtO₂ / acetic acid; H₂O

3: LiAlH₄

With lithium aluminium tetrahydride; potassium ethoxide; hydrogen; platinum(IV) oxide; In water; acetic acid; toluene;

Reference yield:

(7R,7aR)-7-Hydroxy-2-oxo-hexahydro-pyrrolizine-1-carboxylic acid ethyl ester → (+)-croalbinecine (41690-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / acetic acid; H₂O

2: LiAlH₄

With lithium aluminium tetrahydride; hydrogen; platinum(IV) oxide; In water; acetic acid;

upstream raw materials:

Acetic acid (1R,2R,7R,7aR)-1-acetoxymethyl-7-hydroxy-hexahydro-pyrrolizin-2-yl ester

(1S,2R,7R,7aR)-2,7-Dihydroxy-hexahydro-pyrrolizine-1-carboxylic acid ethyl ester

(1S,5S)-2-oxa-6-aza-6-((ethoxycarbonyl)methyl)bicyclo<3.3.0>octan-3-one

Acetic acid (1R,2R,7aR)-1-acetoxymethyl-7-oxo-hexahydro-pyrrolizin-2-yl ester