Technology Process of 2-Cyclohexen-1-one,
3-[(3E)-3-methyl-6-[(4S)-4-(1-methylethenyl)-1-cyclohexen-1-yl]-3-hexen
yl]-
There total 5 articles about 2-Cyclohexen-1-one,
3-[(3E)-3-methyl-6-[(4S)-4-(1-methylethenyl)-1-cyclohexen-1-yl]-3-hexen
yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-1-iodo-6-(4-isopropenyl-1-cyclohexenyl)-3-methyl-3-hexene;
With
tert.-butyl lithium;
In
tetrahydrofuran;
3-Ethoxycyclohex-2-en-1-one;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(02)02491-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C
1.2: tetrahydrofuran / 10 h / 20 °C
2.1: 19.9 g / Ba(OH)2*H2O / aq. ethanol / 19 h / Heating
3.1: 93 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
4.1: PBr3; sym-collidine; LiBr / diethyl ether / 10 h / -78 - 20 °C
4.2: 73 percent / ZnBr2 / diethyl ether / 15 h / -78 - 0 °C
5.1: 92 percent / NaI / acetone / 2.5 h / Heating
6.1: 2,2'-bipyridine; t-BuLi / tetrahydrofuran; pentane / 1.5 h / -78 °C
6.2: 64 percent / tetrahydrofuran; pentane / 1 h / -78 °C
With
2,4,6-trimethyl-pyridine; [2,2]bipyridinyl; barium dihydroxide; lithium aluminium tetrahydride; tert.-butyl lithium; phosphorus tribromide; sodium hydride; sodium iodide; lithium bromide;
In
tetrahydrofuran; diethyl ether; ethanol; acetone; pentane;
5.1: Finkelstein reaction;
DOI:10.1055/s-2004-815956
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 92 percent / NaI / acetone / 2.5 h / Heating
2.1: 2,2'-bipyridine; t-BuLi / tetrahydrofuran; pentane / 1.5 h / -78 °C
2.2: 64 percent / tetrahydrofuran; pentane / 1 h / -78 °C
With
[2,2]bipyridinyl; tert.-butyl lithium; sodium iodide;
In
tetrahydrofuran; acetone; pentane;
1.1: Finkelstein reaction;
DOI:10.1055/s-2004-815956
