2-amino-9-[(2-hydroxy-2-oxido-1,3,2-dioxaphosphinan-5-yl)methoxy]-3,9-dihydro-6H-purin-6-one

Base Information

Chemical Name:2-amino-9-[(2-hydroxy-2-oxido-1,3,2-dioxaphosphinan-5-yl)methoxy]-3,9-dihydro-6H-purin-6-one
CAS No.:123240-63-1
Molecular Formula:C₉H₁₂N₅O₆P
Molecular Weight:317.198
Hs Code.:
Mol file:123240-63-1.mol

Synonyms:6H-Purin-6-one,2-amino-1,9-dihydro-9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)methoxy]-,P-oxide; 1,3,2-Dioxaphosphorinane, 6H-purin-6-one deriv.

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-9-[(2-hydroxy-2-oxido-1,3,2-dioxaphosphinan-5-yl)methoxy]-3,9-dihydro-6H-purin-6-one

Chemical Property:

Vapor Pressure:1.46E-15mmHg at 25°C
Boiling Point:606.5°Cat760mmHg
Flash Point:320.6°C
Density:2.18g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-amino-9-[(2-hydroxy-2-oxido-1,3,2-dioxaphosphinan-5-yl)methoxy]-3,9-dihydro-6H-purin-6-one

There total 6 articles about 2-amino-9-[(2-hydroxy-2-oxido-1,3,2-dioxaphosphinan-5-yl)methoxy]-3,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 114809-39-1
BRL45148

: 123240-63-1
2-Amino-9-(2-hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-5-ylmethoxy)-1,9-dihydro-purin-6-one

Guidance literature:: With tin(IV) chloride; trichlorophosphate; In acetonitrile; 1.) RT, 1 h, 2.) 16 h;
DOI:10.1021/jm00163a031

Reference yield:

: 116477-30-6
4,6-dichloro-2,5-diformamido-pyrimidine

: 123240-63-1
2-Amino-9-(2-hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-5-ylmethoxy)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / diisopropylethylamine / bis-(2-methoxy-ethyl) ether / 2.5 h / 100 °C

2: 81 percent / various solvent(s) / 2 h / 120 °C

3: 63 percent / NH₃ / methanol / 7.5 h / 110 °C / autoclave

4: 78 percent / 80percent acetic acid / 4 h / Ambient temperature

5: 45 percent / 1.) 80percent aq formic acid, 2.) aq NH₃ / 1.) 100 deg C, 2 h, 2.) RT, 0.5 h

6: 10 percent / 1.) stannic chloride, 2.) phosphoryl chloride / acetonitrile / 1.) RT, 1 h, 2.) 16 h

With ammonium hydroxide; formic acid; ammonia; tin(IV) chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1021/jm00163a031

Reference yield:

: 114800-63-4
2,6-diamino-9-(3-hydroxy-2-hydroxymethylprop-1-oxy)purine

: 123240-63-1
2-Amino-9-(2-hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-5-ylmethoxy)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / 1.) 80percent aq formic acid, 2.) aq NH₃ / 1.) 100 deg C, 2 h, 2.) RT, 0.5 h

2: 10 percent / 1.) stannic chloride, 2.) phosphoryl chloride / acetonitrile / 1.) RT, 1 h, 2.) 16 h

With ammonium hydroxide; formic acid; tin(IV) chloride; trichlorophosphate; In acetonitrile;
DOI:10.1021/jm00163a031