8-chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline(SALTDATA: FREE)

Base Information

• Chemical Name: 8-chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline(SALTDATA: FREE)
• CAS No.: 50593-65-2
• Molecular Formula: C11H8ClNO2
• Molecular Weight: 221.643
• Mol file: 50593-65-2.mol

Synonyms:4-Chlor-6,7-methylendioxy-chinaldin;8-chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline;6-metil-8-cloro-1,3-diossol<4,5-g>chinolina;

Chemical Property of 8-chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline(SALTDATA: FREE)

Chemical Property:

• Vapor Pressure: 0.0002mmHg at 25°C
• Boiling Point: 337.8oC at 760 mmHg
• Flash Point: 158.1oC
• PSA: 31.35000
• Density: 1.419g/cm3
• LogP: 2.92530

Purity/Quality:

NLT 98% ^*data from raw suppliers

8-Chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline is a useful reagent in the preparation of 4-?quinolylazide derivatives that exhibits antitumor and antimicrobial properties.

Technology Process of 8-chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline(SALTDATA: FREE)

There total 5 articles about 8-chloro-6-methyl[1,3]dioxolo[4,5-g]quinoline(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-methyl[1,3]dioxolo[4,5-g]quinolin-8(5H)-one → 6-metil-8-cloro-1,3-diossol<4,5-g>chinolina (50593-65-2)

Guidance literature:

With trichlorophosphate; at 0 - 80 ℃;

DOI:10.1016/j.bmc.2010.01.061

Reference yield:

6-metil-8-ossi-1,3-diossol<4,5-g>chinolina (50593-64-1) → 6-metil-8-cloro-1,3-diossol<4,5-g>chinolina (50593-65-2)

Guidance literature:

With trichlorophosphate; In neat (no solvent); at 170 ℃; for 1h;

Reference yield:

benzo[1,3]dioxolo-5-ylamine (14268-66-7) → 6-metil-8-cloro-1,3-diossol<4,5-g>chinolina (50593-65-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 h / Heating

2: neat (no solvent) / 0.33 h

3: POCl₃ / neat (no solvent) / 1 h / 170 °C

With trichlorophosphate; In neat (no solvent);

upstream raw materials:

6-metil-8-ossi-1,3-diossol<4,5-g>chinolina

benzo[1,3]dioxolo-5-ylamine

β-(3,4-metilendiossifenilammino)crotonato di etile

Downstream raw materials:

6-metil-8-mercapto-1,3-diossol<4,5-g>chinolina

6-methyl-8-(4-nitrophenoxy)[1,3]dioxolo[4,5-g]quinoline

N-(6-Methyl-[1,3]dioxolo[4,5-g]quinolin-8-yl)-N'-[1-(2,4,6-trimethoxy-phenyl)-meth-(E)-ylidene]-hydrazine

NSC332397