3-Pyridinecarboxamide, 1,2-dihydro-2-thioxo-

Base Information

• Chemical Name: 3-Pyridinecarboxamide, 1,2-dihydro-2-thioxo-
• CAS No.: 50596-67-3
• Molecular Formula: C6H6N2OS
• Molecular Weight: 154.19000
• Mol file: 50596-67-3.mol

Synonyms:3-carbamyl-2(1H)-pyridinethione;3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Boc-pyrrolidine-3-carboxyamide;1-tert-<(butyloxy)carbonyl>-3-carbamoylpyrrolidine;1-Boc-3-Carbamoylpyrrolidine;1-Boc-pyrrolidine-3-carboxamide;2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid amide;1,2-dihydro-2-thioxo-3-pyridinecarboxamide;3-Aminocarbonyl-1-Boc-pyrrolidine;tert-butyl 3-(aminocarbonyl)pyrrolidine-1-carboxylate;

Chemical Property of 3-Pyridinecarboxamide, 1,2-dihydro-2-thioxo-

Chemical Property:

• PSA: 94.78000
• LogP: 1.16950

Purity/Quality:

99% ^*data from raw suppliers

2-sulfanylpyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxamide, 1,2-dihydro-2-thioxo-

There total 14 articles about 3-Pyridinecarboxamide, 1,2-dihydro-2-thioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,2-dihydro-2-thioxopyridine-3-carbonitrile (52505-45-0) → 1,2-dihydro-2-thioxo-3-pyridinecarboxamide (50596-67-3)

Guidance literature:

With sulfuric acid; at 60 ℃; for 24h;

Reference yield: 78.0%

3-(3-Carbamoyl-pyridin-2-ylsulfanyl)-propionic acid methyl ester → 1,2-dihydro-2-thioxo-3-pyridinecarboxamide (50596-67-3)

Guidance literature:

With sodium methylate; In methanol; for 1h; Heating;

Reference yield: 75.0%

3-carboxy-2-mercaptopyridine (38521-46-9) → 2-mercapto-3-pyridinecarboxamide (50596-67-3)

Guidance literature:

3-carboxy-2-mercaptopyridine; With thionyl chloride; In toluene; for 3h; Reflux;

With ammonia; ammonium chloride; In water; at 20 ℃; Further stages;

DOI:10.1016/j.bmc.2011.01.063

upstream raw materials:

3-carboxy-2-mercaptopyridine

1,2-dihydro-2-thioxo-3-pyridinecarbonyl chloride

1,2-dihydro-2-thioxopyridine-3-carbonitrile

2,2'-dithiobis(3-pyridinecarbonyl chloride)

Downstream raw materials:

2-(3,4-dichlorobenzyl)isothiazolo[5,4-b]pyridin-3(2H)-one

2-(4-fluorobenzyl)isothiazolo[5,4-b]pyridin-3(2H)-one

2-(3,4-difluorobenzyl)isothiazolo[5,4-b]pyridin-3(2H)-one

2-(4-methylbenzyl)isothiazolo[5,4-b]pyridin-3(2H)-one

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