Benzoic acid, 4-(oxiranylmethoxy)-, ethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-(oxiranylmethoxy)-, ethyl ester
• CAS No.: 50625-94-0
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 50625-94-0.mol

Synonyms:4-(2,3-Epoxy-propoxy)-benzoesaeure-aethylester;ethyl p-(2,3-epoxy)-propyloxybenzoate;4-(2,3-epoxy-propoxy)-benzoic acid ethyl ester;2,3-Epoxy-1-[4-(ethoxycarbonyl)-phenoxy]-propane;Ethyl 4-(2,3-Epoxypropoxy)benzoate;1-(4-ethoxycarbonyl)phenoxy-2,3-epoxypropane;

Chemical Property of Benzoic acid, 4-(oxiranylmethoxy)-, ethyl ester

Chemical Property:

• PSA: 48.06000
• LogP: 1.64090

Purity/Quality:

99% ^*data from raw suppliers

4-Oxiranylmethoxy-benzoicacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-(oxiranylmethoxy)-, ethyl ester

There total 3 articles about Benzoic acid, 4-(oxiranylmethoxy)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Ethyl 4-hydroxybenzoate (120-47-8) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → ethyl 4-(glycidyloxy)benzoate (50625-94-0)

Guidance literature:

With sodium carbonate; N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c3gc37088g

Reference yield:

4-hydroxy-benzoic acid (99-96-7) → ethyl 4-(glycidyloxy)benzoate (50625-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄, 3A molecular sieves / 72 h / Heating

2: K₂CO₃ / acetone / 20 h / Heating

With 3 A molecular sieve; sulfuric acid; potassium carbonate; In acetone;

DOI:10.1021/jm00354a003

Reference yield:

→ ethyl 4-(glycidyloxy)benzoate (50625-94-0)

Guidance literature:

upstream raw materials:

Ethyl 4-hydroxybenzoate

epichlorohydrin

4-hydroxy-benzoic acid

Downstream raw materials:

4-(2-hydroxy-3-isopropylamino-propoxy)-benzoic acid ethyl ester

8-<<2-hydroxy-3-(p-ethoxycarbonyl)phenoxypropyl>thio> adenosine

C₂₁H₂₄O₇

2-[3-[(p-ethyloxycarbonyl)-phenoxy]-2-hydroxy-propylthio]-benzothiazole