6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXYLIC ACID
• CAS No.: 50639-66-2
• Molecular Formula: C₁₃H₁₂ClNO₂
• Molecular Weight: 249.697
• Hs Code.: 2933990090
• Mol file: 50639-66-2.mol

Synonyms:6-chloro-1,2,3,4,9-pentahydro-4aH-carbazolylamine;6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-ylamine hydrochloride;1H-CARBAZOL-1-AMINE,6-CHLORO-2,3,4,9-TETRAHYDRO;

Chemical Property of 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 494.6±45.0 °C(Predicted)
• PKA: 4.58±0.20(Predicted)
• PSA: 53.09000
• Density: 1.444±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 3.32580

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXYLIC ACID

There total 3 articles about 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid ethyl ester (49844-36-2) → 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid (50639-66-2)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 1h;

DOI:10.1021/jm050522v

Reference yield:

ethyl 3-bromo-2-oxocyclohexanecarboxylate (30132-23-1) → 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid (50639-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 3 h / 150 °C

2: 91 percent / aq. NaOH / ethanol / 1 h / 20 °C

With sodium hydroxide; In ethanol;

DOI:10.1021/jm050522v

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid (50639-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Br₂ / diethyl ether / 1.5 h / 0 - 20 °C

2: 77 percent / 3 h / 150 °C

3: 91 percent / aq. NaOH / ethanol / 1 h / 20 °C

With sodium hydroxide; bromine; In diethyl ether; ethanol;

DOI:10.1021/jm050522v

upstream raw materials:

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid ethyl ester

ethyl 3-bromo-2-oxocyclohexanecarboxylate

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

EX-527