Methacrylic acid, carbomethoxymethyl ester

Base Information

• Chemical Name: Methacrylic acid, carbomethoxymethyl ester
• CAS No.: 13318-09-7
• Molecular Formula: C7H10O4
• Molecular Weight: 158.1519
• DSSTox Substance ID: DTXSID00157982
• Wikidata: Q83026137
• Mol file: 13318-09-7.mol

Synonyms:METHACRYLIC ACID, CARBOMETHOXYMETHYL ESTER;13318-09-7;2-oxoethoxymethyl 2-methylprop-2-enoate;Carbomethoxymethyl methacrylate;BRN 1771687;AI3-08762;2-Propenoic acid, 2-methyl-, 2-methoxy-2-oxoethyl ester;50G;DTXSID00157982;LS-89914

Chemical Property of Methacrylic acid, carbomethoxymethyl ester

Chemical Property:

• Vapor Pressure: 0.279mmHg at 25°C
• Boiling Point: 203.3°Cat760mmHg
• Flash Point: 79.1°C
• PSA: 52.60000
• Density: 1.082g/cm³
• LogP: 0.27870
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 158.05790880
• Heavy Atom Count: 11
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)OCOCC=O

Technology Process of Methacrylic acid, carbomethoxymethyl ester

There total 5 articles about Methacrylic acid, carbomethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

glycolic acid methyl ester (96-35-5) + Methacryloyl chloride (920-46-7,26937-45-1) → 2-methoxy-2-oxoethyl methacrylate (13318-09-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

→ 2-methoxy-2-oxoethyl methacrylate (13318-09-7)

Guidance literature:

at 500 - 550 ℃; Pyrolysis;

Reference yield:

methyl chloroacetate (96-34-4) → 2-methoxy-2-oxoethyl methacrylate (13318-09-7)

Guidance literature:

With methanol; hydroquinone;

upstream raw materials:

methyl chloroacetate

glycolic acid methyl ester

Methacryloyl chloride

Refernces

• 1、 Shi, Xiaoxiao,Hou, Meili,Bai, Shuang,Ma, Xiaoqian,Gao, Yong-E,Xiao, Bo,Xue, Peng,Kang, Yuejun,Xu, Zhigang,Li, Chang Ming. "Acid-Activatable Theranostic Unimolecular Micelles Composed of Amphiphilic Star-like Polymeric Prodrug with High Drug Loading for Enhanced Cancer Therapy". . p. 4032 - 4041. Retrieved 2017.
• 2、 -. "In response to the pH of such amphiphilic rod-like adriamycin polymer prodrugs of preparation method". Paragraph 0034; 0040; 0042. . Retrieved 2019/11/13.