Benzeneacetonitrile, 4-fluoro-a-(1-methylethyl)-

Base Information

Chemical Name:Benzeneacetonitrile, 4-fluoro-a-(1-methylethyl)-
CAS No.:51632-22-5
Molecular Formula:C11H12FN
Molecular Weight:177.221
Hs Code.:

Synonyms:

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Chemical Property of Benzeneacetonitrile, 4-fluoro-a-(1-methylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of Benzeneacetonitrile, 4-fluoro-a-(1-methylethyl)-

There total 3 articles about Benzeneacetonitrile, 4-fluoro-a-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: ethyl 2-cyano-2-(4-fluorophenyl)-3-methylbutanoate

: 51632-22-5
2-(4-fluorophenyl)-3-methylbutanenitrile

Guidance literature:: With sodium chloride; In water; dimethyl sulfoxide; at 140 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jacs.6b11610

Reference yield:

: 7054-58-2,15032-42-5
ethyl 2-cyano-2-(4-fluorophenyl)acetate

: 51632-22-5
2-(4-fluorophenyl)-3-methylbutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C / Inert atmosphere

2: sodium chloride / dimethyl sulfoxide; water / 5 h / 140 °C / Inert atmosphere

With potassium carbonate; sodium chloride; In water; dimethyl sulfoxide;
DOI:10.1021/jacs.6b11610

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 51632-22-5
2-(4-fluorophenyl)-3-methylbutanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere; Glovebox

2: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C / Inert atmosphere

3: sodium chloride / dimethyl sulfoxide; water / 5 h / 140 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; palladium diacetate; potassium carbonate; sodium chloride; In 1,4-dioxane; water; dimethyl sulfoxide;
DOI:10.1021/jacs.6b11610