5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-oxo-3-[4-(phen ylmethyl)-1-piperidinyl]propyl]phenyl ester

Base Information

Chemical Name:5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-oxo-3-[4-(phen ylmethyl)-1-piperidinyl]propyl]phenyl ester
CAS No.:516473-36-2
Molecular Formula:C36H41N3O6S
Molecular Weight:643.804
Hs Code.:

5-Isoquinolinesulfonic acid,
4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-oxo-3-[4-(phen
ylmethyl)-1-piperidinyl]propyl]phenyl ester

Synonyms:

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Chemical Property of 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-oxo-3-[4-(phen ylmethyl)-1-piperidinyl]propyl]phenyl ester

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Technology Process of 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-oxo-3-[4-(phen ylmethyl)-1-piperidinyl]propyl]phenyl ester

There total 3 articles about 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-oxo-3-[4-(phen ylmethyl)-1-piperidinyl]propyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 84468-15-5
5-isoquinolinesulfonyl chloride

: 516473-08-8
1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-benzylpiperidine

: 516473-36-2
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-benzylpiperidine

Guidance literature:: 1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-benzylpiperidine; With sodium hydride; In tetrahydrofuran; for 0.166667h;

5-isoquinolinesulfonyl chloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm021049d

Reference yield:

: 31252-42-3
4-benzylpyperidine

: 516473-36-2
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-benzylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / EDC; HOBt / dimethylformamide / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 90 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm021049d

Reference yield:

: 82038-34-4
(S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-hydroxyphenyl)propanoic acid

: 516473-36-2
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-benzylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / EDC; HOBt / dimethylformamide / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 90 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm021049d